Evidence map›Paper›PMID 39987379›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Medical treatment of gastroesophageal reflux in the neonatal intensive care unit: current practice.

Chelsea Lockyear, Ashley Stark, Henry P Foote, Anthony Agyeman, Manar Bouleqcha, Noam Cohen, Clare Matusevich, Ansley Pantsari, Shuyan Wang, Sharla Rent and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chelsea LockyearDepartment of Pediatrics, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-0162-6219
Ashley StarkDepartment of Pediatrics, Duke University, Durham, NC, USA.
Henry P FooteDepartment of Pediatrics, Duke University, Durham, NC, USA.
Anthony AgyemanDuke Clinical Research Institute, Durham, NC, USA.
Manar BouleqchaDuke Clinical Research Institute, Durham, NC, USA.
Noam CohenDuke Clinical Research Institute, Durham, NC, USA.
Clare MatusevichDuke Clinical Research Institute, Durham, NC, USA.
Ansley PantsariDuke Clinical Research Institute, Durham, NC, USA.ORCID http://orcid.org/0009-0002-0245-5087
Shuyan WangDuke Clinical Research Institute, Durham, NC, USA.ORCID http://orcid.org/0009-0004-3354-2057
Sharla RentDepartment of Pediatrics, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-8577-478X
William MalcolmDepartment of Pediatrics, Duke University, Durham, NC, USA.
Veeral N ToliaPediatrix Center for Research, Education, Quality, and Safety, Sunrise, FL, USA.
Rachel G GreenbergDepartment of Pediatrics, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-4156-8543
Samia AleemDepartment of Pediatrics, Duke University, Durham, NC, USA. samia.aleem@duke.edu.ORCID http://orcid.org/0000-0003-0291-7608

Funding

COVID-19 Supplement - Center for Innovative TRIals in ChilDrEN and AdulTs (TRIDENT)U24TR001608 · NCATS · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K., HERNANDEZ, ADRIAN · 2016 to 2022
$177.0M
NIH Summer Research Experience Programs (R25)R25HD076475 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2013 to 2023
$1.1M
Duke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training ProgramT32HD104576 · NICHD · DUKE UNIVERSITY · PI BROUWER, KIM L.R., GONZALEZ, DANIEL · 2021 to 2025
$962k
Duke | Duke University School of Medicine | Duke Clinical Research Institute (DCRI) 5R25HD076475-10NCATS NIH HHS U24 TR001608NICHD NIH HHS HHSN275201000003INICHD NIH HHS R25 HD076475NICHD NIH HHS T32 HD104576U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1T32HD104576U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) U24TR001608
6 · The paper itself

Abstract

objectiveTo determine current prescribing practice of acid-suppressive therapy in preterm infants admitted to the neonatal intensive care unit (NICU). STUDY

designCohort study of infants 22 to 27 weeks gestation discharged from Pediatrix Medical Group NICUs between 2015 and 2020.

resultsOf 13,735 infants meeting inclusion criteria, 11% were exposed to acid-suppressive therapy during hospitalization, with 3% of those treated on the day of discharge. Exposed infants had lower birthweights (BW) (p < 0.001). 42% of infants exposed to acid-suppressive therapy received a gastroesophageal reflux disease (GERD) diagnosis (p < 0.001). Median (25th-75th percentile) duration of use was 7 (4-14) days. Use decreased overall during the 5-year period (p < 0.001).

conclusionAcid-suppressive therapies are used commonly in preterm infants and receipt is higher in infants with lower BWs. Use has significantly decreased over time and appears to be targeted, with many infants treated for one-week courses and without a diagnosis of GERD.

Indexed as

Gastroesophageal RefluxInfant, Premature, DiseasesIntensive Care Units, NeonatalPractice Patterns, Physicians'Proton Pump InhibitorsFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleRetrospective StudiesProton Pump Inhibitors

Identifiers

PMID39987379
PMCPMC12226233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.