ArticleJournal of neurology2025
Effectiveness of CT perfusion in posterior circulation stroke: evaluation of perfusion abnormalities and associated clinical signs.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Revascularization treatment for posterior circulation ischemic stroke: a systematic review and network meta-analysis.BMC neurology · 2025Pooled it
- Where Does the Signal Go? Technical Challenges of CT Perfusion in Lacunar and Infratentorial Stroke.Tomography (Ann Arbor, Mich.) · 2026Review
- Challenges and Adjunctive Use of CT Perfusion (CTP) in Acute Stroke: Pitfalls, False Negatives, and Diagnostic Clues for Stroke Mimics.Current neurology and neuroscience reports · 2026Review
- CT Perfusion in lacunar stroke: a powerful tool to enhance lacunar stroke detection and prediction of patients' outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Predictors of Mortality in Posterior Circulation Ischemic Stroke.Medicina (Kaunas, Lithuania) · 2026Article
- Crossed cerebellar diaschisis on CT perfusion in large vessel occlusion stroke: early predictors and clinical relevance in the hyperacute phase.Journal of neurology · 2026Article
- Multimodal Radiomics Model Combining HR-VWI and Clinical Features for Identifying Symptomatic Basilar Atherosclerotic Plaques.BioMed research international · 2026Article
- Assessment of Variability in Cerebral Blood Flow and Cerebral Blood Volume in Cerebral Arteries of Ischemic Stroke Patients Using Dynamic Contrast-Enhanced MRI.Tomography (Ann Arbor, Mich.) · 2025Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAcute posterior circulation stroke (PCS) is characterized by often non-specific clinical signs, with neuroimaging playing a pivotal role in assessment in the emergency setting. The aim of this study was to investigate the effectiveness of CT Perfusion (CTP) maps in detecting acute PCS and to identify clinical factors associated with perfusion abnormalities.
methodsWe retrospectively analyzed clinical and radiological data of consecutive patients with acute PCS admitted to our Stroke Unit that underwent CTP. Follow-up NECT or MRI was performed to confirm the diagnosis of PCS. The effectiveness of CTP to identify PCS was evaluated as the ratio of the CTP in which perfusion abnormalities, compatible with an ischemic event, were present in at least one CTP map among MTT, CBF, TTP, and CBV. Multivariate logistic regression analysis was conducted to identify clinical factors associated with perfusion abnormalities.
resultsCTP showed alterations in 69 of 107 PCS (64.5%) included in final analysis and MTT proved to be the most sensitive. Multivariate analysis showed that atrial fibrillation (OR = 8.571, CI 95% 2.224-33.037, p = 0.002), dyslipidemia (OR = 0.285, CI 95% 0.100-0.814, p = 0.019), visual field deficits (OR = 3.372, CI 95% 1.020-11.150, p = 0.046), and higher neurological deficit (NIHSS > 5) (OR = 4.054, CI 95% 1.147-14.331, p = 0.030) were significantly associated with perfusion abnormalities on CTP.
conclusionCT perfusion can be a valuable resource for detecting acute PCS showing a moderately high positivity rate, higher than that of NECT alone or CTA. These findings contribute to the growing body of evidence supporting the use of perfusion imaging in acute posterior circulation stroke.
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