Evidence map›Paper›PMID 39987298›Full record

ArticleMaternal and child health journal2025

Changes in Hospital Care of Newborn Infants with Trisomy 13.

Allison O Ignatz-Hoover, Mohsen A A Farghaly, Anna Crist, Alshimaa Abdalla, Hany Aly, Mohamed A Mohamed

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Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Allison O Ignatz-Hoover *Neonatal Intensive Care Unit, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue #M31, Cleveland, OH, 44195, USA.
Mohsen A A Farghaly *Neonatal Intensive Care Unit, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue #M31, Cleveland, OH, 44195, USA. fargham@ccf.org.ORCID http://orcid.org/0000-0002-1475-2145
Anna CristNeonatal Intensive Care Unit, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue #M31, Cleveland, OH, 44195, USA.
Alshimaa AbdallaNeonatal Intensive Care Unit, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue #M31, Cleveland, OH, 44195, USA.
Hany Aly *Neonatal Intensive Care Unit, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue #M31, Cleveland, OH, 44195, USA.
Mohamed A Mohamed *Neonatal Intensive Care Unit, Cleveland Clinic Children's Hospital, 9500 Euclid Avenue #M31, Cleveland, OH, 44195, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the changes over recent years in neonatal survival to discharge, prevalence of adverse events, surgical procedures, tracheostomy and/or gastrostomy tube (G-tube) placement, and length of stay (LOS) in infants with Trisomy 13.

methodsWe identified newborn infants with Trisomy 13 in the National Inpatient Sample in the years 2003-2018. We calculated prevalence of associated conditions. We examined procedures done, and common adverse events associated with each condition, survival rates, and LOS. We also calculated changes in trends over the years.

resultsThe study identified 5792 newborn infants with Trisomy 13. Mortality during neonatal period was 58%. There was no significant change in mortality trends over the years, (p < 0.001). Average LOS was 10 (+ 34) days which had significantly increased over recent years (p < 0.001) and it was highest in conditions of NEC followed by gastrointestinal anomalies and sepsis. Among survivors, 2% were discharged with tracheostomy and 9% with G-tubes. LOS was significantly increased in association with these procedures.

conclusionThere was a slight decrease in infants admitted to neonatal intensive care units with Trisomy 13 over recent years. In-hospital neonatal mortality was unchanged. However, there was a significant increase in LOS, which was increased with procedures such as tracheostomy and G-tube placement, which may reflect a trend toward increasing interventions without a corresponding improvement in mortality.

Indexed as

HospitalizationTrisomy 13 SyndromeFemaleHospital MortalityHumansInfant, NewbornIntensive Care Units, NeonatalLength of StayMaleUnited StatesChromosomal disorderCounselingGeneticNeonateNICU ethicsPalliativePatau syndromeTrisomy 13

Identifiers

PMID39987298
PMCPMC12098476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.