Evidence map›Paper›PMID 39987263›Full record

ArticleNature communications2025

The role of Tyr34 in proton coupled electron transfer and product inhibition of manganese superoxide dismutase.

Jahaun Azadmanesh, Katelyn Slobodnik, Lucas R Struble, Jeffrey J Lovelace, Erika A Cone, Medhanjali Dasgupta, William E Lutz, Siddhartha Kumar, Amarnath Natarajan, Leighton Coates and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. The curious life of human mitochondrial SOD2.International journal of biological macromolecules · 2026
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jahaun AzadmaneshEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0002-3615-7785
Katelyn SlobodnikEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0009-0004-0951-5315
Lucas R StrubleEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.
Jeffrey J LovelaceEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.
Erika A ConeEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.
Medhanjali DasguptaEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0003-2509-3699
William E LutzEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.
Siddhartha KumarEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.
Amarnath NatarajanEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0001-5067-0203
Leighton CoatesSecond Target Station, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, USA.ORCID http://orcid.org/0000-0003-2342-049X
Kevin L WeissNeutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, USA.ORCID http://orcid.org/0000-0002-6486-8007
Dean A A MylesNeutron Scattering Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN, USA.ORCID http://orcid.org/0000-0002-7693-4964
Thomas KrollStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Gloria E O BorgstahlEppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE, USA. gborgstahl@unmc.edu.ORCID http://orcid.org/0000-0001-8070-0258

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
Deciphering the Enzymatic Mechanism of Superoxide DismutaseR01GM145647 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Gloria Borgstahl · 2022 to 2026
$2.3M
NCI NIH HHS P30 CA036727NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM145647U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30CA036727U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01-GM145647
6 · The paper itself

Abstract

Human manganese superoxide dismutase (MnSOD) plays a crucial role in controlling levels of reactive oxygen species (ROS) by converting superoxide (

Indexed as

Superoxide DismutaseTyrosineElectron TransportHumansHydrogen PeroxideManganeseMitochondriaModels, MolecularOxidation-ReductionProtonsReactive Oxygen SpeciesSuperoxidesHydrogen PeroxideManganeseProtonsReactive Oxygen SpeciesSuperoxide DismutaseSuperoxidesTyrosine

Identifiers

PMID39987263
PMCPMC11846855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.