Evidence map›Paper›PMID 39987260›Full record

ArticleArchives of dermatological research2025

Mendelian randomization and colocalization analysis reveal the role of IL-6 signaling pathway in psoriasis and potential therapeutic targets.

Jianye Cao, Tiantao Du, Kaiming He, Ziyao Dai, Xianting Xie, Baiyu Chen, Jia Feng, Tao Xu

Abstract read
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In one paragraph

Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianye Cao *Clinical Medical College, Southwest Medical University, Luzhou, China.ORCID http://orcid.org/0009-0001-5605-0942
Tiantao Du *Clinical Medical College, Southwest Medical University, Luzhou, China.
Kaiming HeDepartment of Thoracic Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Ziyao DaiClinical Medical College, Southwest Medical University, Luzhou, China.
Xianting XieClinical Medical College, Southwest Medical University, Luzhou, China.
Baiyu ChenClinical Medical College, Southwest Medical University, Luzhou, China.
Jia FengDepartment of Laboratory Medicine, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. fj67875@swmu.edu.cn.
Tao XuDepartment of Thoracic Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China. xutao016066@163.com.

Funding

the 2023 Open Fund Project of the Luzhou Key Laboratory of Molecular Diagnosis of Clinical Diseases FZZD2023-01the 2024 Open Research Project of the Sichuan Provincial Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases 24GCZXZD03the Luzhou City Science and Technology Plan Project Program, China 2024JYJ030the Luzhou City Southwest Medical University Joint Project Program, China 2023LZXNYDJ007the Scientific Research Program of Southwest Medical University, China 2022QN071the Sichuan Science and Technology Program, China 2024YFFK0356the Southwest Medical University 2023 Undergraduate Innovation and Entrepreneurship Training Program S202310632181; 2023378the Southwest Medical University 2024 Undergraduate Innovation and Entrepreneurship Training Program 202410632007; S202410632131; 2024386; 2024390
6 · The paper itself

Abstract

IL-6 signaling is critical in the pathogenesis of several autoimmune diseases, including psoriasis and psoriatic arthritis. This study utilized Mendelian randomization (MR) analysis to investigate the genetic associations between IL-6 signaling, soluble IL-6 receptor (sIL-6R) levels, and psoriasis and its arthritis. Additionally, the therapeutic potential of IL-6R inhibitors was evaluated. The study methodology was validated through positive and negative control analysis, with further confirmation of genetic associations via Bayesian factor colocalization analysis. The MR results indicated that upregulation of IL-6 signaling was positively associated with psoriasis (P

Indexed as

Arthritis, PsoriaticInterleukin-6Interleukin-6 InhibitorsPsoriasisReceptors, Interleukin-6Bayes TheoremGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideSignal TransductionIL6 protein, humanIL6R protein, humanInterleukin-6Interleukin-6 InhibitorsReceptors, Interleukin-6IL-6 receptor inhibitionIL-6 signalingMendelian randomizationPsoriasisPsoriatic arthritis

Identifiers

PMID39987260

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.