Evidence map›Paper›PMID 39987230›Full record

ArticleScientific reports2025

Human nasal turbinate stem cells with specific gene signatures (HAS2, CXCL1, KRTAP1-5, GSTT2B, and C4B) attenuate rheumatoid arthritis.

Jaeseon Lee, Hong Ki Min, Jung Yeon Lim, Young-Suk Song, Jung Ho Jeon, Se Gwang Jang, Min-Jun Kim, Youngjae Park, Sun Hwa Park, Sung Won Kim and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Platelet-rich Plasma: ACurrent drug research reviews · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jaeseon Lee *The Rheumatism Research Center (RhRC), The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Hong Ki Min *Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, 05030, Republic of Korea.
Jung Yeon Lim *Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-Daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Young-Suk SongThe Rheumatism Research Center (RhRC), The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Jung Ho JeonDepartment of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-Daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Se Gwang JangThe Rheumatism Research Center (RhRC), The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Min-Jun KimThe Rheumatism Research Center (RhRC), The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Youngjae ParkDivision of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Sun Hwa ParkDepartment of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-Daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Sung Won KimDepartment of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-Daero, Seocho-gu, Seoul, 06591, Republic of Korea. kswent@catholic.ac.kr.
Seung-Ki KwokThe Rheumatism Research Center (RhRC), The Catholic University of Korea, Seoul, 06591, Republic of Korea. seungki73@catholic.ac.kr.

Funding

Korea Health Industry Development Institute HI22C1314National Research Foundation of Korea NRF-2019M3E5D5064110
6 · The paper itself

Abstract

This study aimed to investigate the therapeutic effect of human nasal turbinate-derived stem cells (hNTSCs) on mice with rheumatoid arthritis (RA) and identify hNTSC gene signatures with therapeutic effects on RA. hNTSCs were obtained from 20 healthy controls (HCs) who had undergone nasal turbinate surgery. Collagen-induced arthritis (CIA) mice were used to investigate the therapeutic effects of hNTSCs. The engraftment and migration abilities of hNTSCs were evaluated. CD4

Indexed as

Arthritis, RheumatoidStem CellsTurbinatesAnimalsArthritis, ExperimentalCell DifferentiationCell ProliferationChemokine CXCL1HumansMaleMesenchymal Stem CellsMiceMice, Inbred DBAMiddle AgedOsteoclastsOsteogenesisChemokine CXCL1Gene signaturesMesenchymal stem cellNasal turbinateRheumatoid arthritis

Identifiers

PMID39987230
PMCPMC11846856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.