Evidence map›Paper›PMID 39987147›Full record

ArticleBMC chemistry2025

Synthesis and biological activities of 3-aminoimidazo[1,2-α]pyridine compounds.

Isra Al-Qadi, Michel Hanania, Ismail Warad, Nisreen Al-Hajj, Rand Hazzam, Yousef Salama, Saki Raheem, Nawaf Al-Maharik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isra Al-QadiDepartment of Chemistry, Faculty of Science, An-Najah National University, Nablus, 00970, Palestine.
Michel HananiaDepartment of Chemistry, Faculty of Applied Sciences, Technology and Engineering, Bethlehem University, Bethlehem, 00970, Palestine.
Ismail WaradDepartment of Chemistry, Faculty of Science, An-Najah National University, Nablus, 00970, Palestine.
Nisreen Al-HajjDepartment of Chemistry, Faculty of Science, An-Najah National University, Nablus, 00970, Palestine.
Rand HazzamDepartment of Chemistry, Faculty of Science, An-Najah National University, Nablus, 00970, Palestine.
Yousef SalamaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, 00970, Palestine.
Saki RaheemSchool of Life Sciences, University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK. s.raheem@westminster.ac.uk.
Nawaf Al-MaharikDepartment of Chemistry, Faculty of Science, An-Najah National University, Nablus, 00970, Palestine. n.maharik@najah.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite their importance in cancer treatment, anticancer compounds face significant challenges due to drug resistance and low specificity, creating an urgent need for the discovery of more effective alternative. Herein, we report the synthesis of eleven 3-aminoimidazole[1,2-α]pyridine compounds (9-19) employing the one-pot Groebke-Blackburn-Bienayme three-component reaction (GBB-3CR). The cytotoxicity of the synthesised compounds was evaluated against three cancer cell lines (MCF-7, HT-29, B16F10) and a normal cell (MEF). Considering effectiveness and safety, the results demonstrated that among the eleven synthesised compounds, only compounds 12 and 14 exhibited high inhibitory activity against cancer cell lines. Compound 12 with a nitro group at the C-2 position and a p-chlorophenyl group at C-3 position, showed the highest inhibitory activity against HT-29, with an IC

Indexed as

3-aminoimidazole[1,2-α]pyridine4-chlorophenyl isonitrileAnticancerGBB-3CRMulticomponent reaction

Identifiers

PMID39987147
PMCPMC11847391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.