Evidence map›Paper›PMID 39987135›Full record

ArticleWorld journal of surgical oncology2025

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and intraoperative radiation therapy in the management of gastric cancer: a 10-year single center experience.

Marwan M Alaswad, Tarek Z Arabi, Asma S Alshahrani, Belal N Sabbah, Heba W Jaamour, Abdullah A AlOtry, Tariq W Saleh, Ziad H Alhosainy, Fadwa H Elkordy, Aya I Elnegali and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marwan M AlaswadCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia. Marwanalaswad21@outlook.com.
Tarek Z ArabiCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Asma S AlshahraniDepartment of Population Health, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Belal N SabbahCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Heba W JaamourCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Abdullah A AlOtryCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Tariq W SalehCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Ziad H AlhosainyCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Fadwa H ElkordyCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Aya I ElnegaliCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Mohamed H TlayjehCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Firas E KseibiCollege of Medicine, Alfaisal University, Al Zahrawai Street, Riyadh, Saudi Arabia.
Ayman Z AzzamDepartment of Surgical Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Tarek M AminDepartment of Surgical Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe rationale behind the use of HIPEC involves targeted elimination of microscopic peritoneal metastasis, a common route for GCa dissemination, thereby improving the overall survival and reducing recurrences. Moreover, the reasoning behind the use of IORT is enhanced loco-regional control and, therefore, reducing recurrence rates.

methodsFrom February 2013 to June 2023, all GCa patients who underwent HIPEC plus IORT during surgery were included in this study. Median overall survival (OS) and disease-free (DFS) survival were used to evaluate the efficacy of this treatment strategy amongst GCa patients, along with the rate of occurrence and severity of post-operative complications associated with this treatment strategy.

resultsThe median OS and DFS were 63 and 87 months, respectively. More than one-third of the patients in our cohort did not develop any post-operative complications. In patients who developed post-operative complications, the median number of post-operative complications was 1 (IQR 1-2). Most encountered complications were Clavien-Dindo (CD) grade II complications (33.33%) and no in-hospital mortality was observed.

conclusionsThis complex, multimodal treatment strategy results in a significantly prolonged OS and DFS when compared to other treatment strategies for gastric cancer patients, with no added morbidity or mortality.

Indexed as

Cytoreduction Surgical ProceduresHyperthermic Intraperitoneal ChemotherapyNeoplasm Recurrence, LocalPeritoneal NeoplasmsStomach NeoplasmsAgedCombined Modality TherapyFemaleFollow-Up StudiesHumansIntraoperative CareMaleMiddle AgedPostoperative ComplicationsPrognosisRetrospective StudiesDisease free survivalGastric cancerHyperthermic intraperitoneal chemotherapyIntraoperative radiation therapyOverall survivalPeritoneal carcinomatosis

Identifiers

PMID39987135
PMCPMC11846258

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.