ArticlePerioperative medicine (London, England)2025
Synthetic colloids as priming fluids in cardiopulmonary bypass and postoperative acute kidney injury: a propensity score-matched study.
Article in Perioperative medicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Targeted Albumin Administration in Cardiac Surgery: Refining Perioperative Fluid Strategy.Reviews in cardiovascular medicine · 2025Article
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12 authors.
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Abstract
backgroundThe optimal fluid management strategy for patients undergoing on-pump cardiac surgery was controversial regarding the fluid types. This study aimed to compare the impact of hydroxyethyl starch (HES) and succinylated gelatin on postoperative acute kidney injury (AKI).
methodsThis is a single-center, retrospective study. Adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) between 2018 and 2022 were included. Patients were grouped by the priming solution used: HES (the HES group) or succinylated gelatin (the gelatin group). The primary outcome was the incidence of postoperative AKI, and secondary outcomes included continuous renal replacement therapy (CRRT), blood transfusions, myocardial infarction, lung infection, cerebrovascular events, chest drainage, duration of mechanical ventilation, intensive care unit (ICU) stay, in-hospital mortality, and associated costs. Propensity score matching (PSM) was conducted to adjust for characteristic differences between the two groups.
resultsA total of 14,443 patients were included. After 1:1 propensity score matching, 1880 pairs were analyzed. Baseline characteristics were comparable between the matched groups. The incidence of AKI was significantly lower in the gelatin group (3.0% vs. 5.1%, P = 0.001). No significant differences were found in transfusion requirements after score-matching. The use of HES was independently associated with increased odds of AKI (adjusted odds ratio [aOR], 1.785; 95% CI, 1.262-2.526; P = 0.001). The effects of HES use on the occurrence of postoperative AKI were greater in elderly and female patients.
conclusionThe use of HES as a priming solution in on-pump cardiac surgery was associated with an increased risk of postoperative AKI compared to gelatin, although it did not affect transfusion requirements. These findings highlight the importance of considering the priming solution type in fluid management during cardiac surgery.
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