SynthesisBMC oral health2025
The effects of thyroid function on periodontal status: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Thyroid dysfunction alters gut microbiota composition and alveolar bone levels in female mice.Physiological reports · 2026Article
- Periodontal disease and endocrine imbalance: a molecular pathways perspective.Frontiers in dental medicine · 2026Review
- Association between thyroid disorders and oral health: OHRQoL, KAP and self-rated oral health assessment-A structural equation modelling approach.Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundThyroid dysfunction causes various oral manifestations, while periodontal disease is a chronic inflammatory condition affecting the supporting structures of teeth. This systematic review and meta-analysis aimed to evaluate the effects of thyroid dysfunction on periodontal disease indices, synthesizing evidence to clarify the relationship between these conditions.
methodsA comprehensive search followed PRISMA guidelines across Medline, Scopus, Web of Science, and Google Scholar from inception to September 2024. Studies included adults with diagnosed thyroid dysfunction and healthy controls. Data were extracted on thyroid function tests and periodontal disease indices. The risk of bias and quality of studies were assessed using funnel plots, Begg's and Egger's indices, and the Cochrane tool. Effect sizes were calculated using standard mean difference (SMD) via Comprehensive Meta-Analysis software.
resultsEight studies (seven publications) were included. The analysis revealed that patients with thyroid dysfunction exhibited significantly higher periodontal disease indices than controls, with a pooled SMD of 0.369 (95% CI: 0.194-0.545, p < 0.001). The effects of thyroid dysfunction were found on clinical attachment level and pocket probing depth, but not on other indices like the gingival and plaque indexes. Sensitivity analysis confirmed the robustness of these findings. The quality of studies was low, with notable risks of bias.
conclusionsThyroid dysfunction is associated with increased periodontal disease indices, highlighting the need for further research to explore the underlying mechanisms and improve clinical management strategies for affected patients. Future studies should aim for higher methodological rigor to enhance the reliability of findings.
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Registered trials
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