Evidence map›Paper›PMID 39987076›Full record

ArticleJournal of nanobiotechnology2025

Combination therapy with lipid prodrug liposomes reshapes disease-associated neutrophils to promote the cancer-immunity cycle.

Dezhi Sui, Yanzhi Song, Yihui Deng

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dezhi SuiCollege of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang, 110016, China.
Yanzhi SongCollege of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang, 110016, China. songyanzhi@syphu.edu.cn.
Yihui DengCollege of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang, 110016, China. dengyihui@syphu.edu.cn.

Funding

National Natural Science Foundation of China 81703456National Natural Science Foundation of China 81973271
6 · The paper itself

Abstract

Neutrophils play a critical role in the cancer-immunity cycle and are associated with poor clinical outcomes. Recent research has primarily focused on the targeted delivery, phenotypic reversal, and reprogramming of tumor-associated neutrophils, while the impact of disease-associated neutrophils (DANs) on antitumor therapy remains understudied. Since liposomes, as drug delivery carriers, possess excellent biocompatibility and stability, making them particularly suitable for combination therapy, we optimized the formulation of asymmetrically branched polyethylene glycol-modified mitomycin C lipid prodrug liposomes (PEG

Indexed as

LipidsLiposomesNeoplasmsNeutrophilsProdrugsAnimalsCell Line, TumorDexamethasoneFemaleHumansMiceMice, Inbred C57BLMitomycinPolyethylene GlycolsDexamethasoneLipidsLiposomesMitomycinPolyethylene GlycolsProdrugsCancer-immune cycleDisease-associated neutrophilsLiposomesMitomycin C lipid prodrug

Identifiers

PMID39987076
PMCPMC11846314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.