ArticleRespiratory research2025
Gravitational distribution of regional intrapulmonary shunt assessed by EIT in ARDS.
Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Lung perfusion estimation by saline-contrast EIT without breath hold: a randomized cross-over trial.Critical care (London, England) · 2026Trial
- EIT-guided individualized PEEP titration versus conventional lung-protective ventilation to prevent pulmonary complications in laparoscopic bariatric surgery: a study protocol for a randomized controlled trial.BMC anesthesiology · 2026Article
- EIT-based ventilation phenotypes of left-to-right asymmetry and ventral-to-dorsal center in PEEP titration in ARDS.Respiratory research · 2026Article
- Imaging and pulmonary function techniques in ARDS diagnosis and management: current insights and challenges.Critical care (London, England) · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundRegional ventilation/perfusion (V/Q) mismatch in intrapulmonary shunt in dependent regions has always been considered a hallmark of ARDS. However, little is known about the spatial distribution of shunt, and a clear definition has been lacking. The aim of the study was to propose two phenotypes for the spatial distribution of intrapulmonary shunt using electrical impedance tomography (EIT) and to investigate the clinical characteristics and outcomes in the two preset phenotypes.
methodsA total of 76 ARDS patients who received EIT saline contrast examination were included in this retrospective study. Deadspace(%), Shunt(%), and V/Qmismatch(%) were calculated based on the lung V/Q matching map. EIT maps were divided into two horizontal anterior-to-posterior regions of interest, ranging from gravity-independent regions to gravity-dependent regions. The dosal shunt proportion (Shunt
resultsThe D-shunt group (n = 46) had lower dorsal ventilation, lower dorsal deadspace, and a higher Shunt
conclusionTwo phenotypes of regional shunt gravitational distribution can be revealed by EIT. Patients exhibiting a predominance of dependent shunt were characterized by a higher BMI and extrapulmonary ARDS and may experience faster improvement in oxygenation as well as better clinical outcomes. Further research is necessary to evaluate shunt distribution patterns to guide the individualized treatment of ARDS patients.
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