Evidence map›Paper›PMID 39987028›Full record

ArticleBMC medical research methodology2025

Analysis of temporal survival trends: considerations and best practice.

Mikkel Runason Simonsen, Lars Klingen Gjærde, Lars Hernández Nielsen, Jan Brink Valentin, Rasmus Plenge Waagepetersen, Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen

Abstract read
In one paragraph

Article in BMC medical research methodology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mikkel Runason SimonsenDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark. mikkel.simonsen@rn.dk.ORCID 0009-0001-1119-4782
Lars Klingen GjærdeDepartment of Hematology Sciences, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0002-5496-9955
Lars Hernández NielsenCenter for Clinical Data Science, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID 0000-0002-3715-8528
Jan Brink ValentinDanish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.ORCID 0000-0002-8205-7179
Rasmus Plenge WaagepetersenDepartment of Mathemathical Sciences, Aalborg University, Aalborg, Denmark.ORCID 0000-0001-6911-0089
Tarec Christoffer El-GalalyDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0002-4406-380X
Lasse Hjort JakobsenDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0001-6575-7686

Funding

Danish Data Science Academy 2023-1210Kræftens Bekæmpelse R274-A17146
6 · The paper itself

Abstract

Monitoring quality of healthcare is vital to ensure that changes made to clinical practice achieve the intended goals. Assessing temporal trends due to the accumulated effect of all changes in clinical practice in a given period is essential in quality monitoring. However, this assesment is compplicated by the fact that numerous of changes might occour over time unrelated to the clinical practice. Furthermore, the methods used to assess temporal trends in patient outcomes in the medical literature are heterogeneous, making it difficult to compare results between studies. In this paper, we describe methods that enable researchers to investigate temporal trends in survival data and we discuss their pros and cons. Numerous unrelated changes may occur over time which must be taken into account and disentangled when assessing the improvement in clinical management. The methods and interpretation thereof are exemplified on patients with diffuse large B-cell lymphoma from the Danish lymphoma registry.

Indexed as

Lymphoma, Large B-Cell, DiffuseDenmarkHumansRegistriesSurvival AnalysisCausalityDiffuse large B-cell lymphomaHealthcare monitoringMediation analysis

Identifiers

PMID39987028
PMCPMC11847396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.