Evidence map›Paper›PMID 39986446›Full record

Trial reportThe American journal of cardiology2025

Effects of Year Long Aerobic Exercise on Left Atrial Size in Patients With Left Ventricular Hypertrophy.

Douglas Kyrouac, Nicholas Talbot, James MacNamara, Erin Howden, Michinari Hieda, Christopher Hearon, Tiffany Brazile, Benjamin Levine, Satyam Sarma

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Douglas KyrouacDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Nicholas TalbotDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
James MacNamaraDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Texas.
Erin HowdenHuman Integrative Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Michinari HiedaDepartment of Medicine and Biosystemic Science, Hematology, Oncology, and Cardiovascular Medicine, School of Medicine, Kyushu University, Fukuoka, Japan.
Christopher HearonDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas.
Tiffany BrazileDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Texas.
Benjamin LevineDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Texas.
Satyam SarmaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Texas. Electronic address: Satyam.Sarma@UTSouthwestern.edu.

Funding

Aging Fitness & Failure: Mechanisms of Diastolic DysfunctionR01AG017479 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LEVINE, BENJAMIN D · 2001 to 2016
$7.8M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JONATHAN Charles COHEN · 2022 to 2026
$7.4M
Training in Cardiovascular ResearchT32HL125247 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI JOSEPH A HILL · 2015 to 2026
$4.3M
Sympathetic neural patterns and transduction in obesity-associated hypertensionK99HL153777 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HEARON, CHRISTOPHER M · 2020 to 2021
$269k
NHLBI NIH HHS K99 HL153777NHLBI NIH HHS T32 HL125247NIA NIH HHS R01 AG017479NIDDK NIH HHS P30 DK127984
6 · The paper itself

Abstract

Habitual aerobic exercise is associated with left atrial (LA) enlargement which may increase risk of atrial fibrillation. Patients with LVH and increased LV stiffness may be more predisposed to LA remodeling due to higher LA pressures during exercise. We tested the hypothesis 1 year of aerobic exercise training would increase LA size to a greater extent in patients with LVH than controls. Adults with LVH (n = 53) enriched for increased cardiac risk and LV stiffness and control (CON) subjects (n = 58) were randomized to 1 year of high intensity aerobic exercise (ex) or yoga control. LA and LV volumes were measured using 3D echo. Of 111 participants, 83 had complete data available (LVH: 18 exercisers, 10 yoga; CON: 29 exercisers, 26 yoga). Baseline LA volume indices were similar between groups (LVH: 19.8 ± 4.4 mL/m

Indexed as

Atrial RemodelingExerciseHeart AtriaHypertrophy, Left VentricularAgedEchocardiography, Three-DimensionalFemaleFollow-Up StudiesHumansMaleMiddle AgedOrgan SizeTime FactorsYogacardiac remodelingexerciseleft atriumleft ventricular hypertrophy

Identifiers

PMID39986446
PMCPMC12129699

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.