ArticleThe Lancet. Planetary health2025
The impacts of air pollution on mortality and hospital readmission among Medicare beneficiaries with Alzheimer's disease and Alzheimer's disease-related dementias: a national retrospective cohort study in the USA.
Article in The Lancet. Planetary health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Reduced organic nitrogen compounds dominate the toxicity of PMScience advances · 2026Article
- PMEnvironmental health perspectives · 2026Article
- Combined and synergistic effects of heat and fine particulate matter on hospitalization among patients with Alzheimer's disease and related dementias.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Hospitalized Adults' Willingness to Use Mobile Apps for Air Quality and Heat Monitoring: A Survey-Based Study.International journal of environmental research and public health · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundAlzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) are prevalent neurodegenerative disorders, posing a critical worldwide public health challenge. Ambient air pollution has been identified as a potential risk factor for AD progression based on toxicological and epidemiological studies. We aimed to evaluate the impacts of air pollution-including fine particulate matter (PM
methodsWe constructed a population-based nationwide retrospective cohort including all Medicare fee-for-service beneficiaries (aged ≥65 years) in the contiguous USA (2000-16) hospitalised with AD/ADRD, and followed them up from the year after their first hospitalisation until (1) year of death (mortality cohort) and (2) year of second hospitalisation for any cause (readmission cohort). We calculated annual average PM
findingsOur cohort consisted of 5 544 118 individuals, of whom 4 543 759 (82·0%) died and 3 880 894 (70·0%) were readmitted to the hospital during the study period. The average follow-up times were 3·34 years (SD 2·60) for the mortality cohort and 1·98 years (SD 1·65) for the readmission cohort. In both the mortality and readmission cohorts we found significant associations with each pollutant. For an IQR increase in NO
interpretationWe provide new evidence that among a susceptible population with previous AD/ADRD-related hospitalisations, annual air pollution exposure since first hospitalisation is associated with risk of readmission and death.
fundingNational Institute on Aging.
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