Evidence map›Paper›PMID 39985736›Full record

ReviewAging clinical and experimental research2025

Musculoskeletal diseases, infections and vaccines: state of the art, research perspectives and educational needs.

Fiona Ecarnot, Jotheeswaran Amuthavalli Thiyagarajan, Mario Barbagallo, Jane Barratt, Stefan Constantinescu, Ori Elkayam, Luigi Ferrucci, Mickaël Hiligsmann, Meliha Kapetanovic, Francesco Macchia and 9 more

Abstract readReview
In one paragraph

Review in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Fiona EcarnotSINERGIES, University of Franche-Comté, Besançon, 25000, France. Fiona.ecarnot@Univ-fcomte.fr.
Jotheeswaran Amuthavalli ThiyagarajanDepartment of Maternal, Responsible Officer for Bone Health and Ageing Initiative, Ageing and Health Unit, Newborn, Child, Adolescent Health and Ageing, World Health Organization, Geneva, Switzerland.
Mario BarbagalloDepartment of Internal Medicine and Geriatrics, Geriatric Unit, University of Palermo, Via del Vespro 141, Palermo, 90127, Italy.
Jane BarrattInternational Federation on Ageing, Toronto, Canada.
Stefan ConstantinescuFederation of European Academies of Medicine, Brussels, Belgium.
Ori ElkayamDepartment of Rheumatology, Tel Aviv Medical Center, Tel Aviv Medical Center and the "Sackler" Faculty of Medicine, Tel Aviv, Israel.
Luigi FerrucciIntramural Research Program of the National Institute on Aging, Baltimore, MD, USA.
Mickaël HiligsmannDepartment of Health Services Research, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
Meliha KapetanovicInstitution of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden.
Francesco MacchiaHappy Ageing Alliance, Rome, Italy.
Jean-Pierre MichelUniversity of Geneva, Geneva, Switzerland.
Alberto MiglioreRheumatology Unit, San Pietro Fatebenefratelli Hospital, Rome, 00189, Italy.
Alberto PilottoDepartment of Geriatric Care, Neurology and Rehabilitation, E. O. Galliera Hospitals, Genoa, Italy.
Cornel SieberInstitute for Biomedicine of Aging, Friedrich-Alexander University Erlangen-Nürnberg, Solna, Sweden.
Anja StrangfeldDeutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
Nicola VeroneseSaint Camillus International University of Health Sciences, Rome, Italy.
Davide Liborio VetranoDepartment of Neurobiology, Aging Research Center, Care Sciences and Society, Karolinska Institutet and Stockholm University, Solna, Sweden.
Stefania Maggi *National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy. stefania.maggi@in.cnr.it.
René Rizzoli *Faculty of Medicine and Geneva University Hospitals, Geneva, Switzerland.

Funding

World Health Organization 001
6 · The paper itself

Abstract

Musculoskeletal disorders are a significant public health burden concern, projected to increase in the coming decades, and will substantially contribute to the rising prevalence of functional impairment, frailty and disability in a growing global population. Since persons with musculoskeletal disorders tend to have immune dysfunction, inflammation or be taking immunosuppressive medication, prevention of vaccine-preventable diseases (VPDs) in this group is particularly important. The European Interdisciplinary Council for Aging (EICA) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) jointly convened a 2-day in-person and virtual meeting on 26-27 September 2023, to review the state of the evidence on the link between musculoskeletal diseases, infections and vaccines. We present here the Executive Summary of the proceedings of this meeting. We review the importance of physical activity in preventing or mitigating both musculoskeletal diseases and risk of infection. We summarize current knowledge of the impact of common VPDs on the development and progression of musculoskeletal diseases, and the role of selected vaccines in preventing onset and worsening of frailty and disability in these individuals. This report summarizes the evidence presented at the two-day meeting, highlighting the need to raise awareness among scientists, healthcare professionals, decision-makers, civil society and the general public about the long-term sequelae of VPDs, with focus on the health status of older patients with musculoskeletal diseases.

Indexed as

Musculoskeletal DiseasesVaccine-Preventable DiseasesVaccinesAgedExerciseHumansVaccinesInfectionMusculoskeletal diseaseOlder adultsVaccination

Identifiers

PMID39985736
PMCPMC11846730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.