Evidence map›Paper›PMID 39985688›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2025

New mouse model for inducible hACE2 expression enables to dissect SARS-CoV-2 pathology beyond the respiratory system.

Federica Gambini, Dominik Arbon, Petr Nickl, Vaclav Zatecka, Olha Fedosieieva, Juraj Labaj, Vendula Novosadova, Jana Trylcova, Jan Weber, Jan Prochazka and 2 more

Abstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Federica GambiniLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, Prague, 142 20, Czech Republic.
Dominik ArbonCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prumyslova 595, Vestec, 252 50, Czech Republic.
Petr NicklCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prumyslova 595, Vestec, 252 50, Czech Republic.
Vaclav ZateckaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prumyslova 595, Vestec, 252 50, Czech Republic.
Olha FedosieievaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prumyslova 595, Vestec, 252 50, Czech Republic.
Juraj LabajCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prumyslova 595, Vestec, 252 50, Czech Republic.
Vendula NovosadovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prumyslova 595, Vestec, 252 50, Czech Republic.
Jana TrylcovaInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, 166 10, Czech Republic.
Jan WeberInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, 166 10, Czech Republic.
Jan ProchazkaLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, Prague, 142 20, Czech Republic.
Jana BalounovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prumyslova 595, Vestec, 252 50, Czech Republic. jana.balounova@img.cas.cz.
Radislav SedlacekLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, Prague, 142 20, Czech Republic. radislav.sedlacek@img.cas.cz.

Funding

Czech Academy of Sciences RVO 61388963Czech Academy of Sciences RVO 68378050Czech Science Foundation (GACR) GF22-17139KEuropean Molecular Biology Organization SLG-5404Ministry of Education, Youth and Sports of the Czech Republic LM2023036Ministry of Education, Youth and Sports of the Czech Republic, Programme EXCELES LX22NPO5103
6 · The paper itself

Abstract

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection is not limited to the respiratory tract as receptors, including the angiotensin-converting enzyme 2 (ACE2), are expressed across many tissues. This study employed a new conditional mouse model, Rosa26

Indexed as

Angiotensin-Converting Enzyme 2COVID-19SARS-CoV-2AnimalsDisease Models, AnimalFemaleHumansImmunity, InnateLungMaleMiceMice, TransgenicRespiratory SystemACE2 protein, humanAngiotensin-Converting Enzyme 2Conditional mouse modelhACE2InfectionSARS-CoV-2

Identifiers

PMID39985688
PMCPMC12130128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.