Evidence map›Paper›PMID 39985648›Full record

ArticleScience China. Life sciences2025

Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT.

Tianxiang Gui, Ying Liu, Mingfeng Fu, Han Wu, Pan Su, Xuhui Feng, Mengmeng Zheng, Zixuan Huang, Xudong Luo, Walter F Boron and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science China. Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Inactivation mechanisms of NaCommunications biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianxiang GuiKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China.
Ying LiuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China. liuying@hust.edu.cn.
Mingfeng FuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China.
Han WuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China.
Pan SuKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China.
Xuhui FengKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China.
Mengmeng ZhengKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China.
Zixuan HuangKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China.
Xudong LuoInstitute of Biomedicine and Hubei Key Laboratory of Embryonic Stem Cell Research, College of Basic Medicine, Hubei University of Medicine, Shiyan, 442000, China.
Walter F BoronDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Li-Ming ChenKey Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science & Technology, Huazhong University of Science & Technology, Wuhan, 430074, China. liming.chen@hust.edu.cn.

Funding

Molecular mechanism of Na+ -coupled HCO3- transporters: transport of CO3= and CO2R01DK128315 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI BORON, WALTER F, TAJKHORSHID, EMAD · 2021 to 2024
$2.7M
NIDDK NIH HHS R01 DK128315
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD) is well known as a coenzyme involved in many redox reactions in cellular energy metabolism, or as a substrate for many NAD

Indexed as

NADSodium-Bicarbonate SymportersHEK293 CellsHumansHydrogen-Ion ConcentrationLectins, C-TypeMembrane ProteinsOxidation-ReductionCLECL1 protein, humanLectins, C-TypeMembrane ProteinsNADSodium-Bicarbonate Symportersacid-base transporterAHCYAHCYL1IRBITNADNBCe1SLC4A4

Identifiers

PMID39985648
PMCPMC12097937

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.