ArticleJapanese journal of radiology2025
Effects of target coverage on local recurrence in stereotactic body radiotherapy for early-stage lung squamous cell carcinoma.
Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeThis study investigated effects of target coverage on local recurrence (LR) in stereotactic body radiotherapy (SBRT) for early-stage lung squamous cell carcinoma (SCC). MATERIALS AND
methodsPatients with clinical stage IA1-IIA lung SCC treated with SBRT were included in the analysis. Doses of 48-52 Gy were prescribed to the isocenter of the planning target volume according to the tumor diameter. The primary endpoint was LR. To examine the independent effects of dosimetric factors on LR after adjustment for clinical factors, Fine-Gray model with death as a competing risk was used for evaluation.
resultsAmong all 59 patients analyzed, the median follow-up was 42 months. The 3-year LR rate was 24.0%. Univariate analysis of clinical factors showed that biologically effective dose calculated with an α/β value of 10 (BED
conclusionsITV coverage may be particularly important in SBRT for early-stage lung SCC.
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