Evidence map›Paper›PMID 39985607›Full record

ArticleInternational journal of legal medicine2025

Evaluation of alcohol intoxication on primary and secondary haemostasis - results from comprehensive coagulation testing.

Ronja Sabine Schmölders, Till Hoffmann, Derik Hermsen, Michael Bernhard, Fritz Boege, Michael Lau, Benno Hartung

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Article in International journal of legal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ronja Sabine SchmöldersInstitute of Legal Medicine, University Hospital Düsseldorf, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany. Ronja.schmoelders@lvr.de.ORCID http://orcid.org/0009-0008-3087-7002
Till HoffmannInstitute of Transplantation Diagnostics and Cell Therapeutics, University Hospital Düsseldorf, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
Derik HermsenCentral Institute of Clinical Chemistry and Laboratory Diagnostics, University Hospital Düsseldorf, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
Michael BernhardEmergency Department, University Hospital Düsseldorf, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
Fritz BoegeCentral Institute of Clinical Chemistry and Laboratory Diagnostics, University Hospital Düsseldorf, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany.
Michael LauMathematical Institute, Heinrich Heine University, Universitaetsstr. 1, 40225, Düsseldorf, Germany.
Benno HartungInstitute of Legal Medicine, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlcohol intoxication is known to affect blood coagulation. The specific effects remain poorly understood. Here, we investigate the impact of severe alcohol intoxication on blood clotting by comprehensive coagulation testing.

methodsA prospective study included 21 patients admitted to the emergency department of University Hospital Düsseldorf with severe alcohol intoxication (target blood alcohol concentration > 2 g/l). Platelet function and coagulation was compared between states of alcohol intoxication and soberness using multiple platelet function analysis, thrombelastography and determination of single coagulation factors. The same test panel was used to study in vitro-effects of ethanol on coagulation.

resultsBlood alcohol was correlated with impaired platelet aggregation determined in vivo by functional testing employing ADP and ASPI stimulation. Blood alcohol-associated coagulation impairment was not detectable by thrombelastography or clotting factor measurements. Blood alcohol was negatively correlated with von Willebrand factor ratio and clot strength. The association of elevated blood alcohol with impaired coagulation could not be replicated in vitro. DISCUSSION: Our findings suggest that alcohol impairs primary hemostasis by reducing platelet function, while secondary hemostasis remains largely unaffected. Reversion of effects upon sobering suggest a rather direct impact of alcohol on platelet function. That effect was, however, not replicated in vitro possibly implicating involvement of vascular factors.

conclusionBlood alcohol has a potentially negative impact on platelet function, which should be considered in the clinical management of intoxicated patients, especially in emergency settings. Potential bleeding risks due to increased blood alcohol are possibly detected by analysis of platelet function, while not by thrombelastography or plasmatic coagulation tests.

Indexed as

Alcoholic IntoxicationBlood CoagulationHemostasisAdultBlood Coagulation FactorsBlood Coagulation TestsEthanolFemaleHumansMaleMiddle AgedPlatelet AggregationPlatelet Function TestsProspective StudiesThrombelastographyBlood Coagulation FactorsEthanolAlcoholisationBlood coagulationImpedance aggregometryPlatelet functionPost mortemThromelastography

Identifiers

PMID39985607
PMCPMC12170711

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.