Evidence map›Paper›PMID 39985590›Full record

ArticleNeurosurgical review2025

Seizure presentation and incidence-associated factors in treated cerebral arteriovenous malformations: a secondary analysis of the MISTA consortium.

Daniel Sconzo, Felipe Ramirez-Velandia, Sandeep Muram, Alejandro Enriquez-Marulanda, Nimer Adeeb, Sandeep Kandregula, Hamza Adel Salim, Basel Musmar, Adam A Dmytriw, Douglas Kondziolka and 48 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

58 authors.

Daniel SconzoDivision of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Felipe Ramirez-VelandiaDivision of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Sandeep MuramDivision of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Alejandro Enriquez-MarulandaDivision of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nimer AdeebDepartment of Neurosurgery, Louisiana State University, Shreveport, LA, USA.
Sandeep KandregulaDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Hamza Adel SalimDepartment of Radiology, Louisiana State University, Shreveport, LA, USA.
Basel MusmarDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Adam A DmytriwDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MD, USA.
Douglas KondziolkaDepartment of Neurosurgery, New York University Grossman School of Medicine, New York, NY, USA.
Kareem El NaamaniDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Jason SheehanDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, USA.
Natasha IronsideDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, USA.
Salem TosDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, USA.
Ahmed AbdelsalamDepartment of Neurosurgery, University of Miami, Miami, FL, USA.
Deepak KumbhareDepartment of Neurosurgery, Louisiana State University, Shreveport, LA, USA.
Cagdas AtaogluDepartment of Neurosurgery, University of Wisconsin School of Medicine, Madison, WI, USA.
Muhammed Amir EssibayiMontefiore Einstein Cerebrovascular Research Lab, Department of Neurological Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Abdullah KelesDepartment of Neurosurgery, University of Wisconsin School of Medicine, Madison, WI, USA.
Howard RiinaDepartment of Neurosurgery, New York University Grossman School of Medicine, New York, NY, USA.
Arwin RezaiDepartment of Neurosurgery, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
Johannes PöppeDepartment of Neurosurgery, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
Rajeev D SenDepartment of Neurosurgery, University of Washington, Seattle, WA, USA.
Christoph J GriessenauerDepartment of Neurosurgery, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
Pascal JabbourDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Stavropoula I TjoumakarisDepartment of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Jan-Karl BurkhardtDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Robert M StarkeDepartment of Neurosurgery, University of Miami, Miami, FL, USA.
Ufuk ErginogluDepartment of Neurosurgery, University of Wisconsin School of Medicine, Madison, WI, USA.
Mustafa K BaskayaDepartment of Neurosurgery, University of Wisconsin School of Medicine, Madison, WI, USA.
Laligam N SekharDepartment of Neurosurgery, University of Washington, Seattle, WA, USA.
Michael R LevittDepartment of Neurosurgery, University of Washington, Seattle, WA, USA.
David J AltschulMontefiore Einstein Cerebrovascular Research Lab, Department of Neurological Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Malia McAvoyDepartment of Neurosurgery, University of Washington, Seattle, WA, USA.
Assala AslanDepartment of Radiology, Louisiana State University, Shreveport, LA, USA.
Abdallah AbushehabDepartment of Plastic Surgery, Mayo Clinic Hospital, Rochester, MN, USA.
Christian SwaidDepartment of Neurosurgery, University of Texas at Houston, Houston, TX, USA.
Adib AblaDepartment of Neurosurgery, University of Miami, Miami, FL, USA.
Christopher StapletonDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MD, USA.
Matthew KochDepartment of Neurosurgery, University of Florida, Gainesville, FL, USA.
Visish M SrinivasanDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Peng R ChenDepartment of Neurosurgery, University of Texas at Houston, Houston, TX, USA.
Spiros BlackburnDepartment of Neurosurgery, University of Texas at Houston, Houston, TX, USA.
Mark J DannenbaumDepartment of Neurosurgery, University of Texas at Houston, Houston, TX, USA.
Omar ChoudhriDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Bryan PukenasDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Darren OrbachNeurointerventional Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Edward SmithDepartment of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Markus MöhlenbruchInterventional Neuroradiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Ali AlarajDepartment of Neurosurgery, University of Illinois in Chicago, Chicago, IL, USA.
Ali Aziz-SultanDepartment of Neurosurgery, Brigham and Women Hospital, Harvard Medical School, Boston, MA, USA.
Aman B PatelDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MD, USA.
Hugo H CuellarDepartment of Neurosurgery, Louisiana State University, Shreveport, LA, USA.
Michael LawtonDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Jacques MorcosDepartment of Neurosurgery, University of Texas at Houston, Houston, TX, USA.
Bharat GuthikondaDepartment of Neurosurgery, Louisiana State University, Shreveport, LA, USA.
Philipp TausskyDivision of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Christopher S OgilvyDivision of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. cogilvy@bidmc.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seizures occur in 20-45% of patients with cerebral arteriovenous malformations (AVMs) and can potentially influence their quality of life. Some studies have suggested risk factors influencing their development, but the evidence is limited to small cohorts. To analyze seizure presentation and factors influencing seizure development in patients with cerebral AVMs using a multi-institutional consortium. Retrospective multicenter registry from multiple centers in North America and Europe of patients aged 1 to 89 years who had undergone any intervention for brain AVMs between January 2010 and December 2023. Demographics, functional assessment (modified Rankin Scale; mRS), and AVM characteristics, were evaluated to assess for relationship with seizures using a multivariate generalized linear mixed-effects model. 1,005 AVM patients were analyzed; the median age was 42, 73% had a baseline mRS ≤ 2. The median nidus size was 2.2 cm, and most AVMs were Spetzler-Martin grade II (37%). Seizure was the presenting symptom in 237 patients (24%). After adjusting for significant variables, patient-specific factors associated with seizures were younger age (OR 0.99, CI95% 0.98-1), male sex (OR 1.65, CI95% 1.18-2.30), and smoking history (OR 1.69, CI95% 1.17-2.44). AVM-specific factors associated with seizures included rupture status (OR 0.42, CI95% 0.30-0.61); eloquent cortex (OR 1.61, CI95% 1.13-2.29); frontal (OR 1.54, CI95% 1.01-2.35), temporal (OR 1.93, CI95% 1.26-2.96) and parietal (OR 1.71 CI95% 1.08-2.71) location; larger nidal size (OR = 1.23, CI95% 1.08-1.39), and superficial draining vein location (OR 1.86, CI95% 1.15-3.01). In this multicenter consortium, after controlling for significant variables, the incidence of AVM-related seizures was associated with younger age, male sex, smoking history, larger AVMs, eloquent locations, and AVMs in the frontal, temporal, and parietal cortices. Conversely, rupture status, deep venous drainage, and cerebellar locations were negatively associated with seizures.

Indexed as

Intracranial Arteriovenous MalformationsRegistriesSeizuresAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansIncidenceInfantMaleMiddle AgedRetrospective StudiesArteriovenous malformationsPresentationSeizure

Identifiers

PMID39985590

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