Evidence map›Paper›PMID 39985589›Full record

ArticleCellular and molecular life sciences : CMLS2025

Aminophylline targets miR-128-3p/Slc7a11 axis to attenuate neuronal ferroptosis after traumatic brain injury.

Li Manrui, Yang Xu, Jinyuan Liu, Xiao Zhang, Ruixuan Yuan, Yuwen Sun, Yihan Sun, Qiuyun Yang, Miao Liao, Meili Lv and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Traumatic brain injury-related ferroptosis: current perspectives.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Li Manrui *Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China.
Yang Xu *Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China.
Jinyuan Liu *Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China.
Xiao ZhangInstitute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
Ruixuan YuanDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China.
Yuwen SunDepartment of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200000, China.
Yihan SunDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China.
Qiuyun YangDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China.
Miao LiaoDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China.
Meili LvDepartment of Immunology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China.
Xin HuDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. huxingxxy@gmail.com.
Xiameng ChenDepartment of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China. xmchen990@gmail.com.ORCID http://orcid.org/0000-0003-4393-9053
Weibo LiangDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, 610000, Chengdu, China. liangweibo@gmail.com.

Funding

National Natural Science Foundation of China 82202077Sichuan Province Science and Technology Support Program 23NSFSC4762
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a significant global health issue, characterized by high rates of morbidity and mortality, along with substantial economic strains on healthcare systems. This study explores the potential of Aminophylline (AMP), a medication traditionally used for cardiovascular conditions and bronchiectasis, to enhance TBI outcomes by protecting against neuronal damage. Our findings indicate that AMP treatment significantly reduces neuronal ferroptosis in the cortex, leading to less tissue damage and notable improvements in cognitive and motor functions in mice subjected to controlled cortical impact (CCI). Additionally, we found that TBI resulted in decreased expression of miR-128-3p, a reduction that was further strengthened by AMP treatment. Gain-of-function experiments showed that overexpressing miR-128-3p increases neuronal ferroptosis by targeting Slc7a11, indicating how AMP mitigates cognitive and motor impairments in CCI mice. This study highlights the potential of AMP in treating TBI through the miR-128-3p/Slc7a11 pathway, marking the first report of its protective effects against ferroptosis in TBI.

Indexed as

Amino Acid Transport System y+AminophyllineBrain Injuries, TraumaticFerroptosisMicroRNAsNeuronsAnimalsMaleMiceMice, Inbred C57BLSignal TransductionAmino Acid Transport System y+AminophyllineMicroRNAsMirn128 microRNA, mouseSlc7a11 protein, mouseAminophyllineFerroptosismiR-128-3pSLC7A11Traumatic brain injury

Identifiers

PMID39985589
PMCPMC11846823

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.