ArticleJournal of applied clinical medical physics2025
Quantitative beam optimization for radiotherapy of peripheral lung lesions: A pilot study in stereotactic body radiotherapy.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Advancing stereotactic body radiotherapy through off-axis beam optimization to enable safer treatment of multi-isocenter coplanar targets.Physics and imaging in radiation oncology · 2026Article
- Quantitative beam optimization for radiotherapy of peripheral lung lesions: A pilot study in stereotactic body radiotherapy.Journal of applied clinical medical physics · 2025Article
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8 authors.
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Abstract
backgroundTo quantify beam optimization for stereotactic body radiotherapy (SBRT) of peripheral lung lesions.
methodThe new beam optimization approach was based on maximizing the therapeutic gain (TG) of the beam set by minimizing the average physical depth of the lesion with respect to the beam's eye view (BEV). The new approach was evaluated by replanning the 25 SBRT lesions retrospectively to assess if a better plan is achievable in all aspects. Difference in 25 Gy isodose line volume (IDLV
resultsBeam optimization achieved a better plan in all cases by lowering the depth of treatment with an average of % 20.03 ± 12.30 (3.66%-45.78%). As the depth of treatment decreases, the size of the plan also decreases. We observed a reduction of % 4.64 ± 4.55 (0.02%-21.58%, p < 3.8 × 10
conclusionPhysical depth of the lesion with respect to the BEV is inversely proportional to the TG of a beam-set and can be used as a robust and standard metric to select an appropriate beam-set for SBRT of the peripheral lung lesions. Further evaluation warrants the utility of such concept in routine clinical use.
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