Evidence map›Paper›PMID 39985143›Full record

ArticlePhysiological reports2025

Age-related differences in agility are related to both muscle strength and corticospinal tract function.

Evan G MacKenzie, Nick W Bray, Syed Z Raza, Caitlin J Newell, Hannah M Murphy, Michelle Ploughman

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Evan G MacKenzieRecovery and Performance Laboratory (Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland), St. John's, Newfoundland and Labrador, Canada.
Nick W BrayRecovery and Performance Laboratory (Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland), St. John's, Newfoundland and Labrador, Canada.
Syed Z RazaRecovery and Performance Laboratory (Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland), St. John's, Newfoundland and Labrador, Canada.
Caitlin J NewellRecovery and Performance Laboratory (Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland), St. John's, Newfoundland and Labrador, Canada.
Hannah M MurphyRecovery and Performance Laboratory (Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland), St. John's, Newfoundland and Labrador, Canada.
Michelle PloughmanRecovery and Performance Laboratory (Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland), St. John's, Newfoundland and Labrador, Canada.ORCID https://orcid.org/0000-0002-4594-0077

Funding

Canada Foundation for Innovation (CFI) 33621Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) 169649Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) 173526Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) FRN - 489847Newfoundland and Labrador Research and Development Corporation 5404.1699.104
6 · The paper itself

Abstract

Agility is essential for "healthy" aging, but neuromuscular contributions to age-related differences in agility are not entirely understood. We recruited healthy (n = 32) non-athletes (30-84 years) to determine: (1) if aging is associated with agility and (2) whether muscle strength or corticospinal tract function predicts agility. We assessed muscle strength via a validated knee extension test, corticospinal tract function via transcranial magnetic stimulation, and agility via spatiotemporal values (i.e., leg length-adjusted hop length and hop length variability) collected during a novel propulsive bipedal hopping (agility) task on an electronic walkway. Pearson correlation revealed aging is associated with leg length-adjusted hop length (r = -0.671, p < 0.001) and hop length variability (r = 0.423, p = 0.016). Further, leg length-adjusted hop length and hop length variability correlated with quadriceps strength (r = 0.581, p < 0.001; r = -0.364, p = 0.048) and corticospinal tract function (r = -0.384, p = 0.039; r = 0.478, p = 0.007). However, hierarchical regressions indicated that, when controlling for sex, muscle strength only predicts leg length-adjusted hop length (R

Indexed as

AgingMuscle StrengthPyramidal TractsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedTranscranial Magnetic Stimulationageagilitycorticospinal tractneuromuscular systemtranscranial magnetic stimulation

Identifiers

PMID39985143
PMCPMC11845323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.