Evidence map›Paper›PMID 39984995›Full record

ArticleClinical epigenetics2025

Timing of menarche and menopause and epigenetic aging among U.S. adults: results from the National Health and Nutrition Examination Survey 1999-2002.

Saher Daredia, Dennis Khodasevich, Nicole Gladish, Hanyang Shen, Jamaji C Nwanaji-Enwerem, Anne K Bozack, Belinda L Needham, David H Rehkopf, Julianna Deardorff, Andres Cardenas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Saher DarediaDivision of Epidemiology, School of Public Health, University of California, Berkeley, USA.
Dennis KhodasevichDepartment of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Nicole GladishDepartment of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Hanyang ShenDepartment of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Jamaji C Nwanaji-EnweremDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Anne K BozackDepartment of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Belinda L NeedhamDepartment of Epidemiology, Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan, Ann Arbor, USA.
David H RehkopfDepartment of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Julianna Deardorff *Division of Community Health Sciences, School of Public Health, University of California, Berkeley, USA.
Andres Cardenas *Department of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, 94305, USA. andresca@stanford.edu.

Funding

Race/Ethnicity, DNA Methylation, and Disparities in Cardiovascular Mortality: NHANES 1999-2002R01MD011721 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEEDHAM, BELINDA L., REHKOPF, DAVID H · 2017 to 2021
$3.1M
Common and Distinct Influences of Prenatal and Postnatal Early-Life Adversity on Epigenomic Trajectories in Mexican American ChildrenR01MD016595 · NIMHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI Andres Cardenas, Julianna Deardorff · 2022 to 2026
$3.0M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
NIEHS NIH HHS R01 ES031259NIMHD NIH HHS R01 MD011721NIMHD NIH HHS R01 MD016595
6 · The paper itself

Abstract

Reproductive aging, including timing of menarche and menopause, influences long-term morbidity and mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations of age at menarche (N = 1,033) and menopause (N = 658) with epigenetic aging in a nationally representative sample of women ≥ 50 years. Later age at menopause was associated with lower GrimAge epigenetic age deviation (

Indexed as

AgingEpigenesis, GeneticMenarcheMenopauseAdultAgedAge FactorsDNA MethylationFemaleHumansMiddle AgedNutrition SurveysUnited StatesDNA methylationEpigenetic agingMenarcheMenopause

Identifiers

PMID39984995
PMCPMC11844159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.