Evidence map›Paper›PMID 39984992›Full record

ArticleJournal of translational medicine2025

Analysis of thyroid carcinoma composition and spatial architecture in the progression of dedifferentiation, lymphatic metastasis, and gastric metastasis.

Di Wang, Ruichun Lu, Fenglian Yan, Yansong Lin, Hao Wang, Huabao Xiong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Di Wang *Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, 272067, China.
Ruichun Lu *Department of Cadre Healthcare/Geriatrics, Qingdao Hospital, University of Health Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266017, China.
Fenglian Yan *Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, 272067, China.
Yansong LinDepartment of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Hao WangDepartment of Radiotherapy, Qingdao Hospital, University of Health Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266071, China. wanghao2@qdsslyy.wecom.work.
Huabao XiongInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, 272067, China. xionghuabao@mail.jnmc.edu.cn.

Funding

Chinese National Natural Science Foundation Project 61871382Chinese National Natural Science Foundation Project 81401635Chinese National Natural Science Foundation Project 82171810
6 · The paper itself

Abstract

backgroundGastrointestinal metastases are rare in patients with thyroid carcinoma (TC), and their underlying mechanisms remain unclear. Thus, in this study, we aimed to explore the spatial distribution characteristics of TCs and associated gastrointestinal metastatic cells.

methodsWe used spatial transcriptomics to generate an atlas that captures spatial gene expression patterns in papillary thyroid cancer (PTC), anaplastic thyroid carcinoma (ATC), ATC-associated lymphatic metastasis (ATC-LM), and rare ATC-associated gastric metastasis (ATC-GM).

resultsWe demonstrated that tumor-specific myeloid cells with high SFRP4 expression were correlated with TC dedifferentiation and poor prognosis. Moreover, we validated their close localization to CD44

conclusionsThese findings highlight the dynamic changes in cell composition, intercellular communication, and potential markers associated with TC dedifferentiation and distant metastasis. Further research based on our findings may contribute to improving diagnostic and therapeutic strategies for patients with TC.

Indexed as

Cell DedifferentiationDisease ProgressionLymphatic MetastasisStomach NeoplasmsThyroid NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansHyaluronan ReceptorsMalePrognosisHyaluronan ReceptorsAnaplastic thyroid carcinomaGastric metastasisPapillary thyroid cancerSpatial architectureTissue stem cell

Identifiers

PMID39984992
PMCPMC11844095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.