ArticleLipids in health and disease2025
Association between platelet/high-density lipoprotein cholesterol ratio and blood eosinophil counts in American adults with asthma: a population-based study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Pediatric asthma: positive correlation between platelet-to-HDL-C ratio and blood eosinophil counts.Pediatric research · 2026Article
- Association of platelet to high density lipoprotein cholesterol ratio with coronary lesion severity in middle aged and elderly adults.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to evaluate the relationship between the platelet-to-high-density lipoprotein cholesterol ratio (PHR) and blood eosinophil counts (BEOC) in asthmatic patients, using data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018.
methodsThis research explored the link between PHR and BEOC among adults with asthma, drawing on data from a representative U.S. population sample (n = 3034; NHANES 2011-2018). To assess this relationship, multivariable linear models were employed, alongside subgroup and interaction analyses to identify any potential variations across different groups. Additionally, generalized additive models, smooth curve fitting, and threshold effect analysis were employed to explore the relationships in greater detail. Sensitivity tests were performed to ensure the robustness of the findings.
resultsThe weighted multivariable linear regression analysis showed that after adjusting for all covariables, each one-unit rise in PHR was linked to an increase of 41.61 in BEOC (β: 41.61, 95% CI: 25.25-57.97). Subgroup analyses demonstrated consistency across various categories, reinforcing the significant positive association between PHR and BEOC. Interaction tests indicated that this positive association remained stable regardless of factors such as body mass index, smoking, hypertension, or diabetes, with all interaction P-values greater than 0.05. Additionally, the application of generalized additive models and two-piece linear regression models further confirmed the linear association between PHR and BEOC.
conclusionsOur study indicates that a higher PHR may be associated with an increased risk of elevated BEOC in American adults with asthma. Thus, PHR might be considered a potential marker for predicting elevated BEOC levels in this population.
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