Evidence map›Paper›PMID 39984784›Full record

ArticleDigestive diseases and sciences2025

No Increased Risk of Hepatitis B Virus Infection in Patients with Celiac Disease: A Population-Based Study.

Jacqueline Jossen, Benjamin Lebwohl, Jonas Söderling, Ann-Sofi Duberg, Soo Aleman, Rajani Sharma, Hannes Hagström, Peter H R Green, Jonas F Ludvigsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacqueline JossenDivision of Pediatric Gastroenterology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Benjamin LebwohlDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Jonas SöderlingClinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden.
Ann-Sofi DubergDepartment of Infectious Diseases, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Soo AlemanDepartment of Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Rajani SharmaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Hannes HagströmDivision of Hepatology, Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden.
Peter H R GreenDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Jonas F LudvigssonCeliac Disease Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA. jonasludvigsson@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCeliac disease (CeD) has been associated with a low response to hepatitis B (HBV) vaccination, but guidelines for testing and revaccination among individuals with CeD are sparse. We examined the risk of future HBV among individuals with CeD in a population-based Swedish cohort. Furthermore, we examined the rate of prior HBV infection in CeD patients.

methodsAll individuals in Sweden diagnosed with biopsy-verified CeD between 1990 and 2017 were identified through the ESPRESSO cohort. Each individual with CeD was matched by age, sex, calendar year, and birth country (Nordic vs. other) with up to 5 reference individuals.

resultsWe identified 44,721 CeD and 222,238 reference individuals. The incidence rates of diagnosed HBV were 2.3 and 2.9 per 100,000 person-years, respectively. This represented no association with CeD (HR 0.77 (0.45-1.30)). This null association was similar for those with a Nordic (HR 0.80 (0.40-1.60)) and non-Nordic ((HR 0.31 (0.09-1.08)) country of birth. Rates of prior HBV infection were low (CeD 0.08%, controls 0.06%). This corresponded to a small but insignificant increase among individuals with CeD (odds ratio, OR 1.41 (0.97-2.05).

conclusionIn a population-based Swedish cohort, there was no increased risk of developing HBV in individuals with CeD. This finding does not support current practices of testing and revaccination for HBV. Additional studies should be completed in areas with higher endemic rates of HBV. Slightly higher rates of prior HBV infection in CeD may be secondary to increased testing in those seeking medical care for another disease process.

Indexed as

Celiac DiseaseHepatitis BAdolescentAdultAgedCohort StudiesFemaleHumansIncidenceMaleMiddle AgedRisk FactorsSwedenYoung Adultceliaccoeliaccohortglutenhepatitis B virusliver diseaseSweden

Identifiers

PMID39984784
PMCPMC11972206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.