Evidence map›Paper›PMID 39984734›Full record

ArticleNature immunology2025

STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and T

Li Zhong, Yin-Hu Wang, Sascha Kahlfuss, Miki Jishage, Maxwell McDermott, Jun Yang, Anthony Y Tao, Ke Hu, Lucile Noyer, Dimitrius Raphael and 5 more

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. EZH2 and intracellular CaCellular & molecular immunology · 2026
    Article
  5. Review
  6. Article
  7. Journal of human immunity · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Li ZhongDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-3094-4806
Yin-Hu WangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-3637-8852
Sascha KahlfussDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Miki JishageDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Maxwell McDermottDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0005-9503-0556
Jun YangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Anthony Y TaoDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Ke HuDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Lucile NoyerDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1369-684X
Dimitrius RaphaelDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Devisha PatelDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Tristan E KnightDivision of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI, USA.
Meera ChitlurDivision of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI, USA.
Khaled MachacaCalcium Signaling Group, Research Department, Weill Cornell Medicine, Doha, Qatar; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Stefan FeskeDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA. feskes01@nyumc.org.ORCID http://orcid.org/0000-0001-5431-8178

Funding

CRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6M
Regulation of Follicular T cell Responses in the Lung by Ion ChannelsR01AI130143 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2017 to 2021
$2.4M
The role of ion channels and transporters in B cell functionF30AI164803 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TAO, ANTHONY · 2022 to 2024
$158k
Deutsche Forschungsgemeinschaft (German Research Foundation) KA 4514/1-1NIAID NIH HHS F30 AI164803NIAID NIH HHS R01 AI097302NIAID NIH HHS R01 AI130143Qatar Foundation (Qatar Foundation for Education, Science and Community Development) BMRP programU.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI097302U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI130143U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI164803
6 · The paper itself

Abstract

Stromal interaction molecule 1 (STIM1) is critical for store-operated Ca

Indexed as

Neoplasm ProteinsNFATC Transcription FactorsSTAT1 Transcription FactorStromal Interaction Molecule 1T-Box Domain ProteinsTh1 CellsAnimalsCell DifferentiationGene Expression RegulationHumansInterleukin-12Lymphocyte ActivationMiceSignal TransductionT-bet Transcription FactorInterleukin-12Neoplasm ProteinsNFATC Transcription FactorsSTAT1 protein, humanSTAT1 Transcription FactorSTIM1 protein, humanStromal Interaction Molecule 1T-bet Transcription FactorT-Box Domain Proteins

Identifiers

PMID39984734
PMCPMC12121662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.