ArticleScientific reports2025
Reduced low-density lipoprotein cholesterol levels are associated with increased risk of gestational diabetes mellitus in Chinese women.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Trimester-Specific Serum Lipid Profiles in Gestational Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Maternal Serum Lipid Levels in the Third Trimester and Associated Factors in Vietnam.Obstetrics and gynecology international · 2026Article
- Stress-induced hyperglycemia ratio and gestational diabetes mellitus: a cross-sectional study based on NHANES database.Therapeutic advances in endocrinology and metabolism · 2026Article
- GLIS3 rs7034200 and ADRB3 rs4994 genetic variants associated with an increased risk of gestational diabetes mellitus in Chinese women: a case-control study.BMC pregnancy and childbirth · 2025Article
- Emerging risks of lipid-lowering therapy and low LDL levels: implications for eye, brain, and new-onset diabetes.Lipids in health and disease · 2025Article
- Decreased plasma APOA1 levels are associated with increased severity of placenta accreta spectrum disorders: a nested case-control study.Frontiers in endocrinology · 2025Article
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6 authors.
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Abstract
Lipid levels in women with gestational diabetes mellitus (GDM) have been extensively studied, whether low-density lipoprotein cholesterol (LDL-C) is a risk factor for GDM development remains unclear. This study aimed to investigate the correlation between serum LDL-C levels and the risk of GDM. A case-control study was conducted. Glycolipid metabolic and oxidative stress indicators were measured in 696 women with GDM and 1048 healthy pregnant women. Serum LDL-C levels were significantly lower in the GDM group than in the control group (P < 0.001). Subgroup analysis indicated that reduced LDL-C levels were associated with an increased risk of GDM after adjusting for differences in maternal age, pre-pregnancy body mass index (BMI), gestational age at sampling, fasting glucose and insulin levels, and homeostatic model assessment of insulin resistance (odds ratio [OR] 1.372, 95% confidence interval [CI] 1.050-1.794, P = 0.021 for medium-LDL-C subgroup; OR 1.672, 95% CI 1.219-2.294, P = 0.001 for low-LDL-C subgroup). The risk of GDM decreased by 17.6% per 1 mmol/L increase in LDL-C level (OR 0.824, 95% CI 0.733-0.926, P = 0.001). Furthermore, apolipoprotein (apo) A1 and high-density lipoprotein cholesterol (HDL-C) levels were lower, whereas pre-pregnancy and delivery BMI, triglyceride (TG)/HDL-C ratios, and second-trimester fasting glucose levels were higher in the low-LDL-C GDM subgroup than those in the high- and/or medium-LDL-C GDM subgroups (P < 0.05). ApoA1 and HDL-C levels were lower but TG/HDL-C ratios were higher in the medium-LDL-C GDM subgroup than those in the high-LDL-C GDM subgroup (P < 0.05). We concluded that reduced LDL-C levels were associated with an elevated risk of GDM in the study population. Low LDL-C levels correlated with increased BMI and unfavorable TG, HDL, and glucose metabolism.
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