Evidence map›Paper›PMID 39984655›Full record

ArticleNature cell biology2025

Intratumour oxidative hotspots provide a niche for cancer cell dissemination.

Yoshifumi Ueda, Shigeki Kiyonaka, Laura M Selfors, Keisuke Inoue, Hiroshi Harada, Tomohiro Doura, Kunishige Onuma, Makoto Uchiyama, Ryuhei Kurogi, Yuji Yamada and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Chemo-photothermal synergy ignites antitumor immunity via ferroptosis.Signal transduction and targeted therapy · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yoshifumi UedaDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-4731-4280
Shigeki KiyonakaDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan. kiyonaka@chembio.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-4100-6738
Laura M SelforsDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1317-7353
Keisuke InoueDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.
Hiroshi HaradaLaboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0001-7507-3173
Tomohiro DouraDepartment of Biomolecular Engineering, Nagoya University, Nagoya, Japan.ORCID http://orcid.org/0000-0003-1826-6010
Kunishige OnumaDepartment of Clinical Bio-resource Research and Development, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Makoto UchiyamaDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.
Ryuhei KurogiDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.
Yuji YamadaDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.
Jiacheng H SunDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0001-5932-4972
Reiko SakaguchiDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0001-8450-721X
Yuki TadoDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.
Haruki OmatsuDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.
Harufumi SuzukiDepartment of Biomolecular Engineering, Nagoya University, Nagoya, Japan.
Mike AounDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden.
Takahiro NakayamaDepartment of Breast and Endocrine Surgery, Osaka International Cancer Institute, Osaka, Japan.
Taketoshi KajimotoDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.
Tetsuya YanoCanon Inc., Ota-ku, Japan.
Rikard HolmdahlDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-4969-2576
Itaru HamachiDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-3327-3916
Masahiro InoueDepartment of Clinical Bio-resource Research and Development, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yasuo MoriDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan. mori@sbchem.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0001-7180-1938
Nobuaki TakahashiDepartment of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto, Japan. takahashi@sbchem.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0002-0606-3921

Funding

Cancerfonden (Swedish Cancer Society) 22 2350 Pj 01 HJapan Agency for Medical Research and Development (AMED) 22gm6710005h0001
6 · The paper itself

Abstract

Intratumour heterogeneity represents the hierarchical integration of genetic, phenotypic and microenvironmental heterogeneity. Although single-cell sequencing has clarified genetic and phenotypic variability, the heterogeneity of nongenetic, microenvironmental factors remains elusive. Here, we developed T-AP1, a tumour-targeted probe tracking extracellular H

Indexed as

Hydrogen PeroxideNeoplasmsOxidative StressTumor MicroenvironmentAnimalsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionFemaleHumansMiceNeutrophilsNF-E2-Related Factor 2p38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins c-mycHydrogen PeroxideNFE2L2 protein, humanNF-E2-Related Factor 2p38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins c-myc

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.