Evidence map›Paper›PMID 39984611›Full record

ArticleScientific reports2025

Effects of organic salts of virucidal and antiviral compounds from Nelumbo nucifera and Kaempferia parviflora against SARS-CoV-2.

Dan-Dan Yang, Nopporn Chutiwitoonchai, Feng Wang, Ping Tian, Sanya Sureram, Xiaoguang Lei, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan-Dan YangChulabhorn Graduate Institute, Program in Chemical Sciences, Laksi, Bangkok, 10210, Thailand.
Nopporn ChutiwitoonchaiVirology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Thailand Science Park, Phahonyothin Rd, Pathumthani, 12120, Thailand. nopporn.chu@biotec.or.th.
Feng WangThe Research Center of Chiral Drugs, China-Thailand Joint Research Institute of Natural Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, 201203, Shanghai, China.
Ping TianThe Research Center of Chiral Drugs, China-Thailand Joint Research Institute of Natural Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, 201203, Shanghai, China.
Sanya SureramChulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, 10210, Bangkok, Thailand.
Xiaoguang LeiBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871, Beijing, China.
Chulabhorn MahidolChulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, 10210, Bangkok, Thailand.
Somsak RuchirawatChulabhorn Graduate Institute, Program in Chemical Sciences, Laksi, Bangkok, 10210, Thailand.
Prasat KittakoopChulabhorn Graduate Institute, Program in Chemical Sciences, Laksi, Bangkok, 10210, Thailand. prasat@cri.or.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present work investigates virucidal and antiviral compounds in the extracts of seed embryos of a lotus, Nelumbo nucifera, and a Thai ginseng, Kaempferia parviflora. Separation of the extracts led to the identification of antiviral compounds against SARS-CoV-2. Neferine (1) and nuciferine (3) from N. nucifera, as well as their respective HCl salts (2 and 4), exhibited virucidal and antiviral activities against SARS-CoV-2. Virucidal activity of neferine salt (2) (EC

Indexed as

Antiviral AgentsNelumboPlant ExtractsSARS-CoV-2ZingiberaceaeAnimalsAporphinesBenzylisoquinolinesChlorocebus aethiopsCOVID-19COVID-19 Drug TreatmentHumansVero CellsAntiviral AgentsAporphinesBenzylisoquinolinesneferinenuciferinePlant ExtractsAlkaloid saltsAnti-COVID-19 compoundsBisbenzylisoquinoline alkaloidsHerbal medicineTraditional medicineTrimethoxyflavone

Identifiers

PMID39984611
PMCPMC11845762

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.