Evidence map›Paper›PMID 39984492›Full record

ReviewNPJ microgravity2025

The utility of animal models to inform the next generation of human space exploration.

Isla Duporge, Talmo Pereira, Santiago Castiello de Obeso, Julius G Bright Ross, Stephen J Lee, Allyson G Hindle

Abstract readReview
In one paragraph

Review in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isla DuporgeDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA. Isla.duporge@princeton.edu.
Talmo PereiraSalk Institute for Biological Studies, La Jolla, CA, USA.
Santiago Castiello de ObesoWu Tsai Institute, Yale University, New Haven, CT, USA.
Julius G Bright RossWildlife Conservation Research Unit, Department of Biology, University of Oxford, Oxford, England, UK.ORCID http://orcid.org/0000-0003-2454-1592
Stephen J LeeNational Academy of Sciences, Washington, DC, USA.
Allyson G HindleSchool of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV, USA.

Funding

National Aeronautics and Space Administration (NASA) 80NSSC24K0346
6 · The paper itself

Abstract

Animals have played a vital role in every stage of space exploration, from early sub-orbital flights to contemporary missions. New physiological and psychological challenges arise with plans to venture deeper into the solar system. Advances in chimeric and knockout animal models, along with genetic modification techniques have enhanced our ability to study the effects of microgravity in greater detail. However, increased investment in the purposeful design of habitats and payloads, as well as in AI-enhanced behavioral monitoring in orbit can better support the ethical and effective use of animals in deep space research.

Identifiers

PMID39984492
PMCPMC11845785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.