ArticleNature communications2025
Tandem reductive amination and deuteration over a phosphorus-modified iron center.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Beyond the Active Site: Hydrophobic Microenvironment Engineering for Single-Atom Catalysts.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Plasma-Driven Single-Atom Catalysis: From Synthesis to Catalytic Reactions.Nano letters · 2026Review
- Enhancing Activation of DJACS Au · 2025Article
- Oxygen Vacancies in β-MoOResearch (Washington, D.C.) · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deuterated amines are key building blocks for drug synthesis and the identification of metabolites of new pharmaceuticals, which drives the search for general, efficient, and widely applicable methods for the selective synthesis of such compounds. Here, we describe a multifunctional phosphorus-doped carbon-supported Fe catalyst with highly dispersed isolated metal sites that allow for tandem reductive amination-deuteration sequences. The optimal phosphorus-modified Fe-based catalyst shows excellent performance in terms of both reactivity and regioselectivity for a wide range of deuterated anilines, amines, bioactive complexes, and drugs (>50 examples). Experiments on the gram scale and on catalyst recycling show the application potential of this method. Beyond the direct applicability of the developed method, the described approach opens a perspective for the development of multifunctional single-atom catalysts in other value-adding organic syntheses.
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Registered trials
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