Evidence map›Paper›PMID 39984447›Full record

ReviewNature communications2025

Bio-inspired electronics: Soft, biohybrid, and "living" neural interfaces.

Dimitris Boufidis, Raghav Garg, Eugenia Angelopoulos, D Kacy Cullen, Flavia Vitale

Abstract readReview
In one paragraph

Review in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Developing broad brains: the importance of an early introduction to evolutionary thinking in undergraduate neuroscience programs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  5. Bioelectronic Considerations in Biomedical Microneedles.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Implantable bioelectronic outlet.Science advances · 2026
    Article
  12. Review
  13. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  20. Ecosystem-Centered Robot Design: Toward Ecoresorbable Sustainability Robots (ESRs).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dimitris Boufidis *Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0001-8901-7957
Raghav Garg *Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0002-3501-6892
Eugenia AngelopoulosCenter for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0009-0006-5489-6879
D Kacy CullenDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA. dkacy@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-5355-5216
Flavia VitaleDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA. vitalef@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-8644-550X

Funding

Tissue Engineered Rostral Migratory Stream for Directed Neuronal ReplacementR01NS117757 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CULLEN, DANIEL KACY · 2021 to 2025
$2.9M
Tissue Engineered Nigrostriatal Pathway for Anatomical Tract Reconstruction in Parkinson's DiseaseR01NS127895 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Daniel Kacy Cullen · 2023 to 2026
$2.3M
Alexander S. Onassis Public Benefit Foundation (Onassis Foundation) F ZΤ 011-1/2023-2024National Science Foundation (NSF) CAREER Award 2339748NINDS NIH HHS R01 NS117757NINDS NIH HHS R01 NS127895U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01-NS117757U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01-NS127895
6 · The paper itself

Abstract

Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering to realize biologically-active and/or cell-containing living layers at the tissue-device interface that enable seamless biointegration and novel cell-mediated therapeutic opportunities. This review maps the field of bio-inspired electronics and discusses key recent developments in tissue-like and regenerative bioelectronics, from soft biomaterials and surface-functionalized bioactive coatings to cell-containing 'biohybrid' and 'all-living' interfaces. We define and contextualize key terminology in this emerging field and highlight how biological and living components can bridge the gap to clinical translation.

Indexed as

BiomimeticsElectronicsTissue EngineeringAnimalsBiocompatible MaterialsHumansBiocompatible Materials

Identifiers

PMID39984447
PMCPMC11845577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.