Evidence map›Paper›PMID 39984441›Full record

ArticleNature communications2025

Sub-femtomolar drug monitoring via co-calibration mechanism with nanoconfined DNA probes.

Yonghuan Chen, Xiuying Li, Xinru Yue, Weihua Yu, Yuesen Shi, Zilong He, Yuanfeng Wang, Yu Huang, Fan Xia, Fengyu Li

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yonghuan ChenCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Speed Capability Research, Su Bingtian Center for Speed Research and Training, Jinan University, Guangzhou, PR China.ORCID http://orcid.org/0009-0004-6951-5341
Xiuying LiCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Speed Capability Research, Su Bingtian Center for Speed Research and Training, Jinan University, Guangzhou, PR China.
Xinru YueCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Speed Capability Research, Su Bingtian Center for Speed Research and Training, Jinan University, Guangzhou, PR China.
Weihua YuCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Speed Capability Research, Su Bingtian Center for Speed Research and Training, Jinan University, Guangzhou, PR China.
Yuesen ShiAnti-Drug Technology Center of Guangdong Province, Guangdong Province Key Laboratory of Psychoactive Substances Monitoring and Safety, Guangzhou, PR China.
Zilong HeCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Speed Capability Research, Su Bingtian Center for Speed Research and Training, Jinan University, Guangzhou, PR China.
Yuanfeng WangKey Laboratory of Evidence Science, China University of Political Science and Law, Beijing, PR China.
Yu HuangState Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Material Science and Chemistry, China University of Geosciences, Wuhan, PR China. yuhuang@cug.edu.cn.ORCID http://orcid.org/0000-0001-9981-2823
Fan XiaState Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Material Science and Chemistry, China University of Geosciences, Wuhan, PR China.ORCID http://orcid.org/0000-0001-7705-4638
Fengyu LiCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Speed Capability Research, Su Bingtian Center for Speed Research and Training, Jinan University, Guangzhou, PR China. lifengyu@jnu.edu.cn.ORCID http://orcid.org/0000-0003-2481-6111

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22090050, 22176180National Natural Science Foundation of China (National Science Foundation of China) 22474049, 52003103Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LD21B05000
6 · The paper itself

Abstract

Synthetic drugs fundamentally reshape the illicit drug market due to their low cost, ease of production, and rapid manufacturing processes. However, current drug detection methods, which rely on complex instruments, have limited applicability and often neglect the influence of pH fluctuations, leading to potential bias and unreliable results. Herein, we propose co-calibration DNA probes on a nanoconfined biosensor (N

Indexed as

Biosensing TechniquesDNA ProbesDrug MonitoringIllicit DrugsSubstance Abuse DetectionAptamers, NucleotideCalibrationHumansHydrogen-Ion ConcentrationLimit of DetectionSweatAptamers, NucleotideDNA ProbesIllicit Drugs

Identifiers

PMID39984441
PMCPMC11845792

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.