Evidence map›Paper›PMID 39984435›Full record

ArticleNature communications2025

WNK1-dependent water influx is required for CD4

Joshua Biggs O'May, Lesley Vanes, Leonard L de Boer, David A Lewis, Harald Hartweger, Simone Kunzelmann, Darryl Hayward, Miriam Llorian, Robert Köchl, Victor L J Tybulewicz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Piezo1 dictates KProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Rehydration rescues Il22Nature communications · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joshua Biggs O'MayThe Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0002-3187-5550
Lesley VanesThe Francis Crick Institute, London, NW1 1AT, UK.
Leonard L de BoerThe Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0002-9370-5290
David A LewisThe Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0001-7434-2837
Harald HartwegerThe Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0002-1118-1818
Simone KunzelmannThe Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0002-2678-0549
Darryl HaywardThe Francis Crick Institute, London, NW1 1AT, UK.
Miriam LlorianThe Francis Crick Institute, London, NW1 1AT, UK.ORCID http://orcid.org/0000-0003-2582-6602
Robert KöchlThe Francis Crick Institute, London, NW1 1AT, UK.
Victor L J TybulewiczThe Francis Crick Institute, London, NW1 1AT, UK. Victor.T@crick.ac.uk.ORCID http://orcid.org/0000-0003-2439-0798

Funding

Imperial College London President's PhD ScholarshipRCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V0088757/1Wellcome Trust CC2080
6 · The paper itself

Abstract

Signaling from the T cell antigen receptor (TCR) on CD4

Indexed as

Antibody FormationCD4-Positive T-LymphocytesLymphocyte ActivationProtein Serine-Threonine KinasesWaterWNK Lysine-Deficient Protein Kinase 1AnimalsCell ProliferationMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellSignal TransductionOXSR1 protein, mouseProtein Serine-Threonine KinasesReceptors, Antigen, T-CellStk39 protein, mouseWaterWnk1 protein, mouseWNK Lysine-Deficient Protein Kinase 1

Identifiers

PMID39984435
PMCPMC11845700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.