Evidence map›Paper›PMID 39984282›Full record

ArticleRNA (New York, N.Y.)2025

The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA.

Brian H Carrick, Sarah L Crittenden, MaryGrace Linsley, Stephany J Costa Dos Santos, Marvin Wickens, Judith Kimble

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. RNA-binding is the essential biological function of thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Brian H CarrickDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA bcarrick@mrc-lmb.cam.ac.uk jekimble@wisc.edu.ORCID 0000-0003-0139-3582
Sarah L CrittendenDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.ORCID 0000-0003-3375-9825
MaryGrace LinsleyDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.ORCID 0009-0000-7698-7647
Stephany J Costa Dos SantosDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.ORCID 0000-0002-4147-6756
Marvin WickensDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.ORCID 0000-0002-0593-5740
Judith KimbleDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA bcarrick@mrc-lmb.cam.ac.uk jekimble@wisc.edu.ORCID 0000-0001-5622-2073

Funding

FUNCTION OF POLY(A) AND 3'UTRSR01GM050942 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WICKENS, MARVIN P. · 1994 to 2020
$8.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular regulation of germline developmentR01GM134119 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KIMBLE, JUDITH · 2019 to 2022
$2.2M
NIGMS NIH HHS R01 GM050942NIGMS NIH HHS R01 GM134119NIH HHS P40 OD010440
6 · The paper itself

Abstract

Like all canonical PUF proteins,

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsRNARNA-Binding ProteinsStem CellsAnimalsMutationProtein BindingCaenorhabditis elegans ProteinsRNARNA-Binding ProteinsC. elegansgermline stem cellsPUF partnershipsPUF RNA-binding proteinsperm/oocyte cell fate decision

Identifiers

PMID39984282
PMCPMC12001965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.