Evidence map›Paper›PMID 39984203›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification in Response to Hearing Loss.

Patricia M Quiñones, Michelle Pei, Hemant Srivastava, Ariadna Cobo-Cuan, Marcela A Morán, Bong Jik Kim, Clayton B Walker, Michael J Serafino, Frank Macias-Escriva, Juemei Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Auditory Network Discoherence in Chronic Tinnitus.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Hearing Loss and Audiogenic Seizures Induced by Hypofunctional Prestin Variants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Patricia M QuiñonesCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
Michelle PeiCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
Hemant SrivastavaDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Ariadna Cobo-CuanCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
Marcela A MoránCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
Bong Jik KimCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.ORCID https://orcid.org/0000-0002-6384-2171
Clayton B WalkerCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
Michael J SerafinoCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
Frank Macias-EscrivaCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
Juemei WangCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
James B DeweyCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.ORCID https://orcid.org/0000-0001-5715-9125
Brian E ApplegateCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033.
Matthew J McGinleyDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
John S OghalaiCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, California 90033 oghalai@usc.edu.ORCID https://orcid.org/0000-0003-4241-6189

Funding

Cochlear mechanics in the mouseR01DC014450 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI John S Oghalai · 2015 to 2026
$5.6M
Mechanisms of cochlear synaptopathy after noise or blast traumaR01DC017741 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OGHALAI, JOHN S · 2020 to 2024
$3.1M
Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomesR01EB027113 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI APPLEGATE, BRIAN E. · 2019 to 2022
$2.6M
Elucidating neural circuits and pupil readouts of motivated effortful listeningR01DC017797 · NIDCD · BAYLOR COLLEGE OF MEDICINE · PI MCGINLEY, MATTHEW J · 2019 to 2023
$2.4M
Optical coherence tomography for 3D measures of cochlear mechanics in vivoR01DC013774 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OGHALAI, JOHN S · 2015 to 2019
$2.1M
Otolaryngology Clinician-Scientist Training ProgramR25DC019700 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI John S Oghalai · 2022 to 2026
$1.5M
Role of tonic outer hair cell motility in cochlear amplificationR21DC019209 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DEWEY, JAMES BRADEN · 2020 to 2022
$495k
NIBIB NIH HHS R01 EB027113NIDCD NIH HHS R01 DC013774NIDCD NIH HHS R01 DC014450NIDCD NIH HHS R01 DC017741NIDCD NIH HHS R01 DC017797NIDCD NIH HHS R21 DC019209NIDCD NIH HHS R25 DC019700
6 · The paper itself

Abstract

The mammalian cochlea receives efferent feedback from the brain. Many functions for this feedback have been hypothesized, including on short timescales, such as mediating attentional states, and long timescales, such as buffering acoustic trauma. Testing these hypotheses has been impeded by an inability to make direct measurements of efferent effects in awake animals. Here, we assessed the role of the medial olivocochlear (MOC) efferent nerve fibers on cochlear amplification by measuring organ of Corti vibratory responses to sound in both sexes of awake and anesthetized mice. We studied long-term effects by genetically ablating the efferents and/or afferents. Cochlear amplification increased with deafferentation using VGLUT3

Indexed as

CochleaEfferent PathwaysHearing LossOlivary NucleusAcoustic StimulationAmino Acid Transport Systems, AcidicAnimalsEvoked Potentials, Auditory, Brain StemFemaleMaleMiceMice, Inbred C57BLMice, KnockoutAmino Acid Transport Systems, AcidicSlc17a8 protein, mousebrain statecochleafeedbackhearingoptical coherence tomographyouter hair cellpupillometry

Identifiers

PMID39984203
PMCPMC11984096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.