SynthesisAJNR. American journal of neuroradiology2025
Impact of Smoking on Recurrence and Angiographic Outcomes after Endovascular Treatment of Intracranial Aneurysms: A Systematic Review and Meta-Analysis.
Synthesis in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Conventional endovascular treatment and flow diverter for unruptured small- and medium-sized paraophthalmic segment aneurysms.Frontiers in neurology · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundCerebral aneurysm recurrence remains a critical endpoint in evaluating the success of endovascular treatment. While smoking is a recognized risk factor for aneurysm formation and rupture, its impact on post-treatment angiographic outcomes is unclear due to conflicting evidence. PURPOSE: To systematically assess the association between smoking and angiographic outcomes-including occlusion, recurrence, and retreatment-following endovascular treatment of intracranial aneurysms. DATA SOURCES: A comprehensive search of PubMed, Embase, Scopus, and Web of Science was conducted from inception to June 25, 2024. Bibliographies of included studies were also screened. STUDY SELECTION: Studies were eligible if they involved adult patients with intracranial aneurysms treated via endovascular approaches and reported outcomes stratified by smoking status. Case reports, abstracts, and studies not reporting smoking data were excluded. DATA ANALYSIS: Risk of bias was assessed using the Newcastle-Ottawa Scale. Random-effects meta-analyses were conducted using generalized linear mixed models to estimate risk ratios (RRs) with 95% confidence intervals (CIs). Subgroup, sensitivity, and meta-regression analyses were also performed. DATA SYNTHESIS: Twenty-five studies involving 5,828 patients were included. Smokers had a higher rate of complete aneurysm occlusion (RR 1.12, 95% CI 1.06-1.19; LIMITATIONS: Heterogeneity in smoking definitions, variable follow-up durations, reliance on retrospective data, and limited granularity on smoking intensity (eg, pack-years) may affect interpretation. Results are not generalizable to surgical clipping or long-term outcomes.
conclusionsSmoking is associated with increased complete occlusion rates following flow diversion, but does not significantly impact recurrence or retreatment rates. While smoking cessation remains essential for vascular health, its influence on endovascular treatment efficacy may be limited. Standardized reporting and further mechanistic studies are needed to elucidate smoking's role in aneurysm healing.
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