Evidence map›Paper›PMID 39984137›Full record

ArticleBrain, behavior, and immunity2025

Deficiency of intestinal alkaline phosphatase affects behavior and microglia activity in mice.

Jiajia Dai, Jinsheng Yang, Sen Han, Na Li, Shiyu Wang, Suyun Xia, Hyung-Hwan Kim, Yonghyun Jun, Seeun Lee, Yoshinori Kitagawa and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jiajia DaiMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospital for Children, Boston, MA, the United States of America.
Jinsheng YangMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America.
Sen HanDivision of Genetics, Brigham and Women's Hospital, Boston, MA 02115, the United States of America.
Na LiMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America.
Shiyu WangMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America.
Suyun XiaMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America.
Hyung-Hwan KimDepartment of Radiology, Neurovascular Research Laboratory, Massachusetts General Hospital, Charlestown, MA, the United States of America.
Yonghyun JunDepartment of Radiology, Neurovascular Research Laboratory, Massachusetts General Hospital, Charlestown, MA, the United States of America; Department of Anatomy, School of Medicine, Chosun University, Dong-gu, Dong-gu, Gwangju, South Korea.
Seeun LeeDepartment of Radiology, Neurovascular Research Laboratory, Massachusetts General Hospital, Charlestown, MA, the United States of America.
Yoshinori KitagawaDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospital for Children, Boston, MA, the United States of America; Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.
Fei XieMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospital for Children, Boston, MA, the United States of America.
Liuyue YangMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America.
Shiqian ShenMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America.
Lucy ChenMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America.
Dana P TurnerMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America.
Richard A HodinDepartment of Surgery, Massachusetts General Hospital, Boston, MA, the United States of America.
J A Jeevendra MartynDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospital for Children, Boston, MA, the United States of America.
Jianren MaoMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America. Electronic address: jmao@mgh.harvard.edu.
Zerong YouMGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, the United States of America; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospital for Children, Boston, MA, the United States of America. Electronic address: zyou@mgh.harvard.edu.

Funding

Major Burn Injury and its Effects on Acute and Superimposed Surgical PainR01GM142042 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MARTYN, JEEVENDRA · 2020 to 2023
$1.3M
Establishment and Validation of a Novel Animal Model of FibromyalgiaR61NS133083 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MAO, JIANREN · 2024 to 2024
$418k
NIGMS NIH HHS R01 GM142042NINDS NIH HHS R61 NS133083
6 · The paper itself

Abstract

The gut microbiota plays crucial roles in the development and functions of the central nervous system (CNS) as well as in modulation of neurobehavior in heath and disease. The gut brush border enzyme intestinal alkaline phosphatase (IAP) is an important positive regulator of gut microbial homeostasis. In mice, IAP is encoded by Akp3 gene, which is specifically expressed in the duodenum of the small intestine. IAP deficiency alters gut bacterial composition and gut barrier function. Decreased IAP activity has been observed in aging, gut inflammatory diseases, and metabolic disorders. We hypothesized that this enzyme could also play an important role in modulating neurobehavior. We performed deep sequencing of gut bacterial 16S rRNA and found that IAP deficiency changed gut microbiota composition at various taxonomic levels. Using targeted metabolomic analysis, we also found that IAP deficiency resulted in changes of gut bacteria-derived metabolites in serum and brain metabolism. Neurobehavioral analyses revealed that Akp3

Indexed as

Alkaline PhosphataseBehavior, AnimalMicrogliaAnimalsAnxietyBrainFecal Microbiota TransplantationGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLMice, KnockoutPhagocytosisAlkaline PhosphataseALPL protein, mouseApk3(-/-) miceBehaviorFecal microbiota transplantGut bacteriaIndoleIndole-3-propionic acid (IPA)Intestinal alkaline phosphatase (IAP)MetaboliteMicroglia

Identifiers

PMID39984137
PMCPMC12051184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.