Evidence map›Paper›PMID 39984061›Full record

ArticleFree radical biology & medicine2025

Rabbit model of oxidative stress-induced retinal degeneration.

Yogita Kanan, Jingwen Zhang, Alexandra Bernardo-Colón, Subrata Debnath, Mahmood Khan, S Patricia Becerra, Peter A Campochiaro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yogita KananThe Wilmer Eye Institute, USA. Electronic address: ykanan1@jhmi.edu.
Jingwen ZhangThe Wilmer Eye Institute, USA.
Alexandra Bernardo-ColónNIH-NEI- Section of Protein Structure and Function, Bethesda, MD, USA.
Subrata DebnathNIH-NEI- Section of Protein Structure and Function, Bethesda, MD, USA.
Mahmood KhanThe Wilmer Eye Institute, USA.
S Patricia BecerraNIH-NEI- Section of Protein Structure and Function, Bethesda, MD, USA.
Peter A CampochiaroThe Wilmer Eye Institute, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

ROLE OF PROTEIN INTERACTIONS IN RETINA DEVELOPMENT AND FUNCTIONZ01EY000306 · NEI · NATIONAL EYE INSTITUTE · PI BECERRA, SOFIA P · 1995 to 2008
$2.3M
A novel hypotonic gelling eye drop for topical treatment of retinal degenerative diseasesR01EY031041 · NEI · JOHNS HOPKINS UNIVERSITY · PI CAMPOCHIARO, PETER A, ENSIGN, LAURA · 2020 to 2023
$1.6M
Intramural NIH HHS Z01 EY000306NEI NIH HHS R01 EY031041
6 · The paper itself

Abstract

Retinitis pigmentosa (RP) is a disorder that results in the death of rod photoreceptors in the retina, caused by several different mutations. As rods are 95 % of the photoreceptors in the eye and consume the most oxygen, their death causes tissue hyperoxia resulting in oxidative stress in the retina. Oxidative stress is implicated in the pathogenesis of photoreceptor death in RP. Therefore, oxidative stress models are very relevant to identifying drugs to prevent photoreceptor death in RP. Rabbits are an excellent model to study retinal degeneration due to their large eyes and therefore larger subretinal and vitreous space, makes it easier for surgical and drug interventions techniques. Herein, we have created a rabbit model of oxidative stress-induced retinal degeneration using paraquat (PQ), a known oxidant. PQ causes oxidative stress in the retina, that results in functional and structural loss of photoreceptors. We also show that using an antioxidant PEDF[H105A], we were able to blunt the damage to photoreceptors caused by PQ. Therefore, this rabbit model of oxidative stress-induced retinal degeneration will serve as an excellent model to test a wide array of surgical and drug interventions techniques.

Indexed as

Oxidative StressRetinal DegenerationRetinitis PigmentosaAnimalsAntioxidantsDisease Models, AnimalEye ProteinsNerve Growth FactorsParaquatPigment Epithelium-Derived FactorRabbitsSerpinsAntioxidantsEye ProteinsNerve Growth FactorsParaquatPigment Epithelium-Derived FactorSerpinsAntioxidant: animal modelOxidative stressRetinal degenerationRetinitis pigmentosa

Identifiers

PMID39984061
PMCPMC12706796

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.