Evidence map›Paper›PMID 39984054›Full record

ArticleMucosal immunology2025

Lung-resident memory Th2 cells regulate pulmonary cryptococcosis by inducing type-II granuloma formation.

Keigo Ueno, Akiko Nagamori, Nahoko Oniyama Honkyu, Kyung J Kwon-Chung, Yoshitsugu Miyazaki

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Keigo UenoDepartment of Fungal Infection, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Electronic address: keigo-u@niid.go.jp.
Akiko NagamoriDepartment of Fungal Infection, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Nahoko Oniyama HonkyuDepartment of Fungal Infection, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Kyung J Kwon-ChungMolecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Building 10, Bethesda, MD 20892, United States.
Yoshitsugu MiyazakiDepartment of Fungal Infection, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Funding

Pathogenic differences between Cryptococcus neoformans and C. gattiiZIAAI000744 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KWON-CHUNG, KYUNG · 2010 to 2025
$10.9M
Intramural NIH HHS ZIA AI000744
6 · The paper itself

Abstract

Lung-resident memory T cells (lung TRMs) settle in the lung and respond rapidly to external antigens, and are therefore considered to have great potential for development of respiratory vaccines. Here, we demonstrate that lung-resident memory Th2 cells (lung TRM2) protect against pulmonary mycosis caused by Cryptococcus gattii. We developed novel whole-cell intranasal vaccines using a heat-inactivated C.gattii capsule-deficient strain cap59Δ, which induced ST-2

Indexed as

CryptococcosisCryptococcus gattiiFungal VaccinesGranulomaLungLung Diseases, FungalMemory T CellsTh2 CellsAdoptive TransferAnimalsAntigens, FungalDisease Models, AnimalImmunologic MemoryInterleukin-13Interleukin-4MiceAntigens, FungalFungal VaccinesInterleukin-13Interleukin-4CryptococcosisGranulomaTissue-resident memory T cellsType-II immunity

Identifiers

PMID39984054
PMCPMC12167160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.