Evidence map›Paper›PMID 39984053›Full record

ArticleMucosal immunology2025

Influenza virus-induced type I interferons disrupt alveolar epithelial repair and tight junction integrity in the developing lung.

Abigail P Onufer, Joshua Chang Mell, Laura Cort, Abhishek Rao, Nontokozo V Mdluli, Alison J Carey

Abstract read
In one paragraph

Article in Mucosal immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abigail P OnuferMicrobiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Joshua Chang MellMicrobiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Laura CortMicrobiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Abhishek RaoMicrobiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Nontokozo V MdluliMicrobiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Alison J CareyMicrobiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States; Pediatrics, Drexel University College of Medicine, Philadelphia, PA, United States. Electronic address: ajc327@drexel.edu.

Funding

Mechanisms of age-specific differences in the Type I IFN response to respiratory viral infectionR01AI149801 · NIAID · DREXEL UNIVERSITY · PI CAREY, ALISON J · 2020 to 2022
$1.4M
NIAID NIH HHS L40 AI154583NIAID NIH HHS R01 AI149801
6 · The paper itself

Abstract

Recently, we demonstrated that influenza A virus (IAV)-infected murine neonates lacking a functional IFN-I receptor (IFNAR

Indexed as

Alveolar Epithelial CellsInfluenza A virusInterferon Type ILungOrthomyxoviridae InfectionsTight JunctionsAnimalsAnimals, NewbornCells, CulturedMiceMice, Inbred C57BLMice, KnockoutOccludinReceptor, Interferon alpha-betaSignal TransductionZonula Occludens-1 ProteinIfnar1 protein, mouseInterferon Type IOccludinReceptor, Interferon alpha-betaZonula Occludens-1 ProteinBarrier integrityDevelopmentEpithelial cellsInfluenzaLung repairPediatrics

Identifiers

PMID39984053
PMCPMC12710878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.