ArticleThe Journal of thoracic and cardiovascular surgery2025
Left atrial and ventricular remodeling in chronic mitral regurgitation.
Article in The Journal of thoracic and cardiovascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Case Report: Transthoracic echocardiographic diagnosis of agenesis of mitral chordae tendineae with papillary muscle fusion.Frontiers in cardiovascular medicine · 2026Article
- Improved methodology for establishing a mitral regurgitation animal model guided by intracardiac echocardiography.Quantitative imaging in medicine and surgery · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveThis study describes the structural and mechanical changes in the left atrium and left ventricle in a canine model of chronic mitral regurgitation in an attempt to identify markers linked to the onset of atrial tachyarrhythmias or left ventricle dysfunction.
methodsAnimals underwent baseline and terminal echocardiography and cardiac magnetic resonance imaging. Under echocardiographic guidance, chordae tendinae were avulsed until there was severe mitral regurgitation, defined by regurgitant jet area to left atrium area more than 70%. At terminal surgery, rapid atrial pacing was performed to test inducibility of atrial tachyarrhythmias.
resultsTwelve canines underwent mitral valve chordae avulsion and were kept alive for an average of 8.8 ± 1.3 months. Left atrium volume increased more than 111% (P < .01), left ventricle end-systolic volumes increased more than 57% (P < .01), and left ventricle end-diastolic volumes increased more than 48% (P < .01). Increased left ventricle mass was negatively correlated to ejection fraction (P = .01). During rapid atrial pacing, 6 canines developed inducible atrial arrhythmias. There were no differences in left atrium volume, function, or left ventricle strain between canines with atrial tachyarrhythmias and those without. Independently, 6 developed left ventricle dysfunction with an average decrease in ejection fraction of 16% ± 4%. Canines with reduced ejection fraction experienced markedly increased left atrial volume at minimal filling (P = .02) and impaired left ventricle global radial strain (P = .05).
conclusionsOur experimental canine model replicated electrophysiological and hemodynamic consequences of clinical mitral regurgitation. Although left atrium function and left ventricle strain did not associate with atrial tachyarrhythmia inducibility, left atrial volume at minimal filling, left ventricle mass, and left ventricle global radial strain emerged as potential indicators of left ventricle dysfunction. These markers may have clinical value in guiding timely surgical intervention.
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