ArticlePLOS global public health2025
Factors influencing treatment success in drug-susceptible tuberculosis patients in Ghana: A prospective cohort study.
Article in PLOS global public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Drug resistance patterns and associated risk factors in pulmonary tuberculosis patients from selected hospitals in Ghana.BMC infectious diseases · 2026Article
- Understanding predictors of medication adherence and treatment outcomes among TB patients in the Western Region, Ghana: strategies for strengthening TB control efforts.Journal of health, population, and nutrition · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimal rates of positive tuberculosis (TB) treatment outcomes are crucial for patient well-being and preventing the emergence of drug-resistant strains. Unfavourable outcomes present significant challenges to healthcare systems worldwide, making it essential to identify factors that influence treatment success. This study aimed to assess treatment outcomes and explore determinants of success to inform effective interventions and contribute to TB eradication efforts. Patients with active TB were monitored from treatment initiation to completion between January 2021 and December 2021. Data were collected using a Redcap-based tool to capture demographics, adverse reactions to antitubercular medications, and treatment outcomes. Quality of life was assessed using the Short-Form 12 version 2 questionnaire at baseline, the second month, and the sixth month. Logistic regression was performed to analyse associations between participant characteristics and treatment success, with odds ratios indicating the strength of associations at a 0.05 significance level. Among 378 participants, 77.3% achieved successful treatment outcomes, while 13.5% were lost to follow-up, 0.5% experienced treatment failure, and 8.7% died. Key factors influencing treatment success included baseline body weight, weight gain during treatment, HIV status, adverse drug reactions, and mental well-being at treatment initiation. Multivariate analysis revealed that gaining at least 3 kg during treatment and having no risk of depression at baseline significantly increased the likelihood of treatment success.
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Registered trials
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