Evidence map›Paper›PMID 39982856›Full record

ArticleBiochemistry2025

Quantitative and Systematic NMR Measurements of Sequence-Dependent A-T Hoogsteen Dynamics in the DNA Double Helix.

Akanksha Manghrani, Atul Kaushik Rangadurai, Or Szekely, Bei Liu, Serafima Guseva, Hashim M Al-Hashimi

Abstract read
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In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Nature communications · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Akanksha ManghraniDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27705, United States.ORCID 0000-0002-6498-7305
Atul Kaushik RangaduraiDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27705, United States.
Or SzekelyDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27705, United States.ORCID 0000-0002-9502-9337
Bei LiuDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27705, United States.ORCID 0000-0003-2155-2974
Serafima GusevaDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, United States.
Hashim M Al-HashimiDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, United States.

Funding

Role of DNA structural dynamics in mutagenesis and oncogenesisR01GM089846 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hashim M Al-Hashimi · 2010 to 2026
$5.2M
900 MHz NMR Spectrometer for Structural BiologyP41GM066354 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI COWBURN, DAVID · 2002 to 2006
$4.7M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR015495 · NCRR · NEW YORK STRUCTURAL BIOLOGY CENTER · PI RIFKIND, RICHARD A · 2000 to 2000
$2.0M
Acquisition of a 900 MHz NMR Spectrometer Console and ProbesS10OD030373 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2021 to 2021
$1.7M
Acquisition of 700 MHz NMR SpectrometerS10OD018509 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2015 to 2015
$1.1M
NCRR NIH HHS C06 RR015495NIGMS NIH HHS P41 GM066354NIGMS NIH HHS R01 GM089846NIH HHS S10 OD018509NIH HHS S10 OD030373
6 · The paper itself

Abstract

The dynamic properties of DNA depend on the sequence, providing an important source of sequence-specificity in biochemical reactions. However, comprehensively measuring how these dynamics vary with sequence is challenging, especially when they involve lowly populated and short-lived conformational states. Using

Indexed as

DNABase PairingBase SequenceKineticsMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularNucleic Acid ConformationDNA

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.