Evidence map›Paper›PMID 39982638›Full record

ArticleNeuroscience bulletin2025

Cation Channel TMEM63A Autonomously Facilitates Oligodendrocyte Differentiation at an Early Stage.

Yue-Ying Wang, Dan Wu, Yongkun Zhan, Fei Li, Yan-Yu Zang, Xiao-Yu Teng, Linlin Zhang, Gui-Fang Duan, He Wang, Rong Xu and 5 more

Abstract read
In one paragraph

Article in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Review
  6. Article
  7. Targeting enhancing myelin regeneration reverses cognitive deficits in a mouse model of intellectual disability.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yue-Ying Wang *Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.
Dan Wu *Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.
Yongkun Zhan *Center of Clinical Genetics, School of Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University , Shanghai, 200092, China.
Fei LiDepartment of Developmental and Behavioral Pediatrics, Department of Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.ORCID http://orcid.org/0000-0003-0576-5849
Yan-Yu ZangMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.
Xiao-Yu TengMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.
Linlin ZhangQilu Pharmaceutical Co., Ltd, Jinan, 250100, China.
Gui-Fang DuanState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100091, China.
He WangDepartment of Anesthesiology, Pain and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Rong XuDepartment of Rehabilitation Medicine, Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.
Guiquan ChenMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.
Yun XuMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China.ORCID http://orcid.org/0000-0001-5288-0319
Jian-Jun YangDepartment of Anesthesiology, Pain and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. yjyangjj@126.com.
Yongguo YuCenter of Clinical Genetics, School of Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University , Shanghai, 200092, China. yuyongguo@shsmu.edu.cn.
Yun Stone ShiMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Department of Neurology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210032, China. yunshi@nju.edu.cn.ORCID http://orcid.org/0000-0002-8842-9818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate timing of myelination is crucial for the proper functioning of the central nervous system. Here, we identified a de novo heterozygous mutation in TMEM63A (c.1894G>A; p. Ala632Thr) in a 7-year-old boy exhibiting hypomyelination. A Ca

Indexed as

Cell DifferentiationOligodendrogliaAnimalsCells, CulturedChildHumansMaleMiceMice, KnockoutMyelin SheathOligodendrocyte Precursor CellsHypomyelinationMutationOligodendrocyte differentiationTMEM63A

Identifiers

PMID39982638
PMCPMC11978589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.