Levels of Talin1 in Platelet-Derived Microvesicles Affect Platelet Activation in Patients with Nonvalvular Atrial Fibrillation.

Zhen Liu, Jun Yang, Hongping Chen, Lihui Zhang

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Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Zhen LiuCardiovascular Department, Yantai Yuhuangding Hospital, Shandong University, Yantai, 264099, China.

Jun YangYantai Yuhuangding Hospital, Shandong University, No. 20, Yuhuangding East Road, Zhifu District, Yantai, 264099, China. yangjyhd@163.com.

Hongping ChenCardiovascular Department, Yantai Yuhuangding Hospital, Shandong University, Yantai, 264099, China.

Lihui ZhangCardiovascular Department, Yantai Yuhuangding Hospital, Shandong University, Yantai, 264099, China.

Funding

The Joint Construction Project of Henan Province Medical Science and Technology Research LHGJ20200937

6 · The paper itself

Abstract

This study evaluated talin1 expression in platelets and platelet-derived microvesicles (PMVs) from nonvalvular atrial fibrillation (NVAF) patients. Meanwhile, this study analyzed the impacts of talin1 expression in PMVs on platelet activation. Twelve healthy controls and 38 NVAF patients were recruited in this study. The levels of talin1 and RAP1B activation were observed in the platelets and PMVs from the participants, and their levels were significantly increased in the NVAF patients compared to the healthy controls (P < 0.01). Talin1 silence in MEG-01 cells was obtained by transfecting talin1 siRNA, and the cells were stimulated by thrombin receptor-activating peptide 6 (TRAP-6) to induce platelet-dense granule secretion. TRAP-6 stimulation increased the talin1 expression and RAP1B activation in the platelet-like particles from MEG-01 cells, but talin1 silence suppressed the TRAP-6-stimulated RAP1B activation and CD62p expression in the platelet-like particle. Moreover, the platelets from healthy donors were activated by the PMVs from the TRAP-6-stimulated MEG-01 cells. However, the decreased talin1 level in the PMVs from MEG-01 cells weakened the platelet activation. This study suggested that talin1 expression in the PMVs affected platelet activation in patients with NVAF.

Indexed as

Atrial FibrillationBlood PlateletsCell-Derived MicroparticlesPlatelet ActivationTalinAgedAged, 80 and overCase-Control StudiesFemaleHumansMaleMiddle AgedPeptide Fragmentsrap GTP-Binding ProteinsPeptide FragmentsRAP1B protein, humanrap GTP-Binding ProteinsTalinthrombin receptor peptide (42-47)TLN1 protein, humanMEG-01 cellsNonvalvular atrial fibrillationPlatelet-derived microvesiclesRAP1B activationTRAP-6

Identifiers

PMID39982629

DOI10.3390/ijms232012512

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