Evidence map›Paper›PMID 39982626›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society.

G Devigili, G Di Stefano, V Donadio, I Frattale, L Grazzi, E Mantovani, M Nolano, V Provitera, S G Quitadamo, S Tamburin and 9 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Fibromyalgia: the Italian survey by the ministry of health.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Review
  4. Review
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

G Devigili *Fondazione IRCCS Carlo Besta, Milan, Italy.
G Di StefanoDepartment of Human Neuroscience, Sapienza University, Rome, Italy.
V Donadio *Clinica Neurologica Bellaria Hospital, Bologna, Italy.
I Frattale *Child Neurology and Psychiatric Unit, Tor Vergata University, Rome, Italy.
L Grazzi *Fondazione IRCCS Carlo Besta, Milan, Italy.
E Mantovani *Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
M Nolano *Skin Biopsy Laboratory, Department of Neurology, Istituti Clinici Scientifici Maugeri IRCCS, Telese Terme, Italy.
V Provitera *Skin Biopsy Laboratory, Department of Neurology, Istituti Clinici Scientifici Maugeri IRCCS, Telese Terme, Italy.
S G Quitadamo *DiBrain Department, Bari Aldo Moro University, Bari, Italy.
S Tamburin *Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
A Truini *Department of Human Neuroscience, Sapienza University, Rome, Italy.
M Valeriani *Child Neurology and Psychiatric Unit, Tor Vergata University, Rome, Italy.
A FuriaFondazione IRCCS Carlo Besta, Milan, Italy.
E Vecchio *DiBrain Department, Bari Aldo Moro University, Bari, Italy.
F FischettiDiBrain Department, Bari Aldo Moro University, Bari, Italy.
G GrecoDiBrain Department, Bari Aldo Moro University, Bari, Italy.
A TelescaFondazione IRCCS Carlo Besta, Milan, Italy.
M de TommasoDiBrain Department, Bari Aldo Moro University, Bari, Italy. marina.detommaso@uniba.it.ORCID http://orcid.org/0000-0001-6567-5373
On behhalf of neuropathic pain special interest group of the Italian neurological society (sin)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough fibromyalgia is a disabling disease, there is no targeted therapy for specific neurotransmitters or inflammatory mediators. Our aim was to provide neurologists with practical guidance for the management of these difficult patients based on a critical, narrative and non-systematic review of randomized controlled trials (RCTs) from the last 10 years.

methodsThe members of the Special Interest Group Neuropathic Pain of the Italian Neurological Society evaluated the randomized controlled trials (RCTs) of the last 10 years and answered questions that allow a consensus on the main pharmacological and non-pharmacological approaches.

resultsThe neuropathic pain working group agreed on prescribing antiepileptic drugs or antidepressants in the case of comorbidities with anxiety and depression. As a second choice, experts have agreed on the association of antiepileptics and antidepressants, while they disagree with the use of opioids. Medical cannabis and nutraceuticals are promising new treatment options, although more data is needed to prove their efficacy. The neurologists agreed in suggesting physical activity at the first visit, particularly aerobic and strength training. As a second choice, they considered a cognitive behavioral therapy approach to be useful.

conclusionsPharmacologic treatment with antiepileptic drugs and antidepressants in patients with co-occurring anxiety and depression, as well as an early nonpharmacologic approach based primarily on physical activity, may be a useful indication in contemporary neurology clinical practice. Non-pharmacological options, such as cognitive behavioral therapy and non-invasive brain stimulation NIBS, could improve evidence of efficacy and lead to relevant improvement in FM-related disability.

Indexed as

FibromyalgiaNeuralgiaAnticonvulsantsAntidepressive AgentsConsensusHumansItalyRandomized Controlled Trials as TopicSocieties, MedicalAnticonvulsantsAntidepressive AgentsFibromyalgiaNon-pharmacological therapyPharmacological therapyRecommendationsTreatments

Identifiers

PMID39982626
PMCPMC12003471

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.